J4 ›› 2011, Vol. 37 ›› Issue (1): 93-96.

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Determination of expression of Notch signaling pathway protein |in renal cell carcinoma tissues and its significance

LOU Dong-Mei1,2, MOU Rong3, WU Hui*, LIU Yu-He3, ZHONG Jia-Teng1, YU Chun-Yan3, YANG Dong-Yan4   

  1. 1.Dpartment of Pathophysiology,Norman Bethune College of Medicine,Jilin Univers
    ity|Changchun 130021,China;2.Department of Cardiology,Central Hospital of Changchun,Changchun 130051,China 3.Department of Pathology,School of Basic Medical Sciences,Beihua University,Jilin 132000,China;4.Department of Electrodiagnosis,China-Japan Union Hospital,Jilin University, Changchun 130033,China
  • Received:2010-08-25 Online:2011-01-28 Published:2011-01-28

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Abstract:

Abstract:Objective
To detect the Notch signaling pathway-related protein expression levels in human renal cell carcinoma (RCC)   tissues  and explore the  relationship between Notch signaling pathway molecule and occurrence and  development of RCC.Methods 6 cases of RCC diagnosed by pathology detection were obtained by surgical methods.The Notch signaling pathway receptor and ligand protein levels in RCC tissues and adjacent tissues were detected with Western blotting. Results Compared with adjacent tissues, the expression levels of the receptor of Notch signaling Notch-1 and the ligand Jagged-1 in RCC tissues were  significantly reduced（P<0.05）,the expression levels of the  receptor Notch-2 of the  Notch signaling pathway and the ligand Jagged-2  in RCC tissues were significantly  increased（P<0.05）.Conclusion The expression of N
otch signaling pathway protein in RCC has apparente change,Notch signaling pathway may be involved in the occurrence and development of RCC.

Key words: renal cell carcinoma;Notch signaling pathway;protein expression;Western blotting

CLC Number: 

  • R737.11
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