Abstract:

Abstract:Objective To explore the evidence-based analysis value of cytokeratin 19 (CK19) and epithelial cell adhesion molecule (EpCAM) expressions in gastric cancer. Methods The expressions of CK19 and EpCAM in gastric mucosa (including 31 cases of gastric cancer,7 cases of benign lesions and 16 cases of normal tissues) were detected by microarray-immunohistochemical technique,which were assessed in diagnositic value by evidence-based methods. Results The expressions of CK19 and EpCAM in the benign lesions and gastric cancer tissues were significantly higher than that in the normal tissues (P<0.05). EpCAM had significant positive relevance with infiltration degree(rs=0.514,P<0.05),TNM(rs=0.581,P<0.05),and lymph node metastasis（b=1.376,P<0.05）.The validity,reliability and profit of parallel experiment were higher than those in separate experiment and series experiment of CK19 and EpCAM. Conclusion CK19 and EpCAM are related with the occurrence and development of gastric cancer. The parallel experiment has much more value in evidence-based diagnosis.

Key words: tissue microarray;stomach neoplasms;cytokeratin 19;epithelial cell adhesion molecule;evidence-based diagnosis