Abstract:

Abstract:Objective To discuss the ischemic information with dynamic susceptibility contrast-enhanced MR imaging（DSC-MRI） and artery spin labeling（ASL）technique in the patients with unilateral middle artery stenosis,and confirm the diagnosis value of the ASL perfusion technique in ischemic cerebravascular diseases. Methods 48 patients of transient ischemic attack（TIA）  with unilateral middle cerebral artery (MCA) stenosis or occlusion and 35 healthy volunteers were collected.  The concentration-time curve was got through cerebral blood flow (CBF) map and DSCimages. The difference of the cerebral perfusion in side of the MCA  stenosis was observed by comparing the concentration-time curve between the two methods. Results The rCBF of  ipsilateral MCA stenosis tissues was  （30.4±8.2）mL·100 g^-1·min^-1 and （58.3±11.4） mL·100 g^-1·min^-1  of contralateral tissues detected with  ASL-PWI method ,there was significant difference(P<0.05).The rCBF in  ipsilateral MCA stenosis tissues was （28.7±12.8） mL·100 g^-1·min^-1 and  （54.2±9.5） mL·100 g^-1·min^-1  of contralateral tissues detected with DSC-PWI method(P<0.05).The rCBF of ipsilateral tissue of the same blood vessel detected with ASL andDSC had no significant difference(P>0.05). The rCBF of healthy controls detected with ASL and DSC were （56.8±0.7） mL·100 g^-1·min^-1  and （55.2±9.8） mL·100 g^-1·min^-1 ,there were no significant differences compared with controlateral tissue of MCA stennosis(P>0.05).The apparent diffusion coefficient (ADC) value of ipsilateral MCA stenosis was （522.3±57.2×10^-6）mm²·s^-1 and （756.8±67.6×10^-6）mm²·s^-1  in contralateral tissue detected with DWI method,there was significant differerce(P<0.05). Conclusion ASL can measure the CBF data and  the extent of low perfusion in MCA  stenosis and occlusion;ASL in combination with DWI can indicate the ischemic penumbra in MCA stenosis patients.

Key words: dynamic susceptibility contrast-enhancement；artery spin labeling；ischemic penumbra；transient ischemic attack