J4 ›› 2011, Vol. 37 ›› Issue (3): 509-512.
Previous Articles Next Articles
WANG Ying|YANG Hua|WANG Lian-you|CUI Ya-nan|ZHANG Li-rong
Received:
Online:
Published:
Abstract:
Objective To investigate the feature and difference of protein expression in neoplastic cells and non-neoplastic background lymphoid cells of classical Hodgkin lymphoma.Methods The clinical data,histological features and immunohis tochemical findings of sixty-eight cases of classical Hodgkin lymphoma were collected.The additional immunostaining was performed if conformed by Envision method,the CD30,CD15 and T/B phenotype and so forth were mainly observed. Results The expression rates of CD30 in neoplastic cells and background lymphoid cells were 86.76%(59/68)and 20.59%(14/68). The expression rates of CD15 in neoplastic cells and background lymphoid cells were 51.47%(35/68)and 63.24%(43/68). The positive rates of T-cell and B-cell phenotypes in neoplastic cells were 45.59%(31/68) and 42.65%(29/68). The expressions of B-cell and T-cell phenotype in neoplastic cells were 21 cases and 28 cases while mature lymphoid cells mainly expressed T-cell phenotype.The expressions of B-cell and T-cell phenotypes in neoplastic cells were 8 cases and 3 cases while mature lymphoid cells mainly expressed non T-cell phenotype.Conclusion Both CD30 and CD15 are not specific markers,they could express both in neoplastic cells and reactive lymphocytes.The T-cell phenotype expressed in neoplastic cells is higher than B-cell phenotype.There is no difference of positive rate between T-cell or B-cell phenotype in neoplastic cells while background cells mainly express T-cell phenotype.
Key words: Hodgkin lymphoma/pathology;neoplastic cells;lymphoid cells;immunophenotype
CLC Number:
WANG Ying|YANG Hua|WANG Lian-you|CUI Ya-nan|ZHANG Li-rong. Expressions of |relative markers of neoplastic cells andbackground lymphoid cells in classical Hodgkin lymphoma [J].J4, 2011, 37(3): 509-512.
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: http://xuebao.jlu.edu.cn/yxb/EN/
http://xuebao.jlu.edu.cn/yxb/EN/Y2011/V37/I3/509
Cited