Abstract:

Abstract:Objective To study the association between urotensin Ⅱ (UTS2) S89N  gene single nucleotide polymorphism(SNP)  and serum lipid level in essential hypertension(EH) patients in Dongxiang population.Methods The genotypes of UTS2-S89N of 102 normal persons(control group) and 120 EH  patients (case group) were conducted by PCR -RFLP and agarose gel electrophoretic analysis.The serum lipid levels was detected by automatic biochemical analyzer.The association between genotypes of UTS2-S89N and the serum lipid level in Dongxiang population was analyzed.Results The levels of  TC,TG,and LDL-C in case group.were higher than those in control group(P<0.01).In case group,the level of LDL-C of the  patients with SS gentype(2.76±1.02) was higher than those of the  patients with NN genotype(2.34±0.37) and NS genotype (2.12±0.65)(P<0.05).The levels of TC,TG and HDC-C had no significnat differences between various genotypes in two groups(P>0.05).Conclusion The SS genotype  of UTS2-S89N gene is associated with the serum lipid of the  EH patients in Dongxiang population.

Key words: Dongxiang population;serum lipid;essential hypertension;single nucleotide polymorphism;urotensin Ⅱ gene