Abstract:

Objective To study the clinic value of DTPA renal dynamic imaging in the functional evaluation of infantile hydronephrosis and clarify its applicational value，and lay the foundation for DTPA renal dynamic imaging in  diagnosis and treatment of infantile hydronephrosis.Methods 70 infants with hydronephrosis in our hospital whose mean age was （2.32±2.1） years (rang from 37 d to 6 years) were selected.There were 56 males and 14 females.18 normal infants with mean age (2.66±2.01) years (rang from 41 d to 6 years,15 males and 3 females) were selected as control group during the same period.Technetium-99m-labelled DTPA (^99mTc-DTPA) was taken as agent,and the dose of ^99mTc was 18.5MBq per infant.GE Infinia SPECT was used as imaging equipment.The time-activity curve was generated in the imaging system automatically.The glomerular filtration rate (GFR) was detected by DTPA renal dynamic imaging through drawing the region of interest (ROI).Results 83 kidneys were suffered from hydronephrosis diagnosed by B-ultrasound among 70 infant patients,while 104 abnormal kidneys were diagnosed by renal dynamic imaging.The detection rate of renal dysfunction by renal dynamic imaging was higher than that of B-ultrasound (t=7.751,P=0.005).Among 83 kidneys suffered from hydronephrosis diagnosed by B-ultrasound,the continued rising type was 56 cases (67.47%);the parabolic type was cases (7.23%);the high linear extension type was 14 cases (16.87%);and the low linear extension type was 7 cases (8.43%). The GFR value of linear extension type was lower than normal control group,the difference was significant (P<0.05),and the another three types had no significant diffirences compared  with control group.Conclusion For infantile hydronephrosis,DTPA renal dynamicimaging can observe not only the abnormal morphology of kidney,but also the function of split kidney;and it can provide objective basis for  diagnosis and treatment of infantile hydronephrosis.

Key words: hydronephrosis;99mTc -DTPA;radioistope renography;ultrasonography