Abstract: Abstract:Objective To investigate the therapeutic  effect of gink gobioba extract (GBE) on diabetic cardiomyopathy (DCM) induced by streptozotocin (SZT) and isoprenaline (ISO) in rats. Methods 20 male Wistar rats were randomly divided into normal control group(n=5),model group(n=5),positive control group(n=5),and treatment group (n=5).The rats in normal control group were given nothing and the other rats were given STZ and ISO to construct DCM rat models.The rats in model group were given saline and the rats in positive control group and treatment groupwere given benazepril and GBE,respectively.The body weight,blood sugar level,serum AST and LDH levels,expression level of TGF-β1 protein,and morphology of myocardium of rats  in various groups were observed. Results 1 and 2  weeks after treatment,the body weight and blood sugar level of the  rats  in model group were lower than those in  normal control group（P<0.05）. The body weights and blood sugar levels of the rats in positive control and treatment group were lower than those in  normal control group（P<0.05）. The levels of AST,LDH,and TGF-β1 in model group were higher than those in   normal group(P<0.05）;and the levels of AST,LDH,and TGF-β1 in positive control and treatment group were higher than those in model group(P<0.05).The myocardial  cells of the  rats in normal control group had no swelling.The cells in model group showed clear boundaries and more scattered necrosis,and there were lots of fibroblasts  and some collagen fibers in focal necrosis.The myocardial cells of the  rats intreatment group had smaller focal necrosis and lower fibrosis.Conclusion GBE can alleviate myocardial injury induced by STZ plus ISO of rats.

Key words: ginkgo biloba extract, streptozotocin, isoproterenol, transforming growth factor-&beta