Journal of Jilin University Medicine Edition ›› 2013, Vol. 39 ›› Issue (3): 517-520.doi: 10.7694/jldxyxb20130319
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WU Guo-dong1,WANG Su-xia1,JI Zhi-yong1, ZHANG Shu-yan2
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Abstract: Objective To study the relationship between the level of B-type natriuretic peptide(BNP) and liver function of rats with acute decompensated heart failure and to explore the values of the changes of liver function in evaluation of curative effect and prognosis of the patients with heart failure.Methods 60 male SD rats were chosen and intraperitoneally injected with isoproterenol for establishment of acute decompensated heart failure models.20 rats were randomly selected from the survival rats after successful modeling as heart failure group.And 20 normal rats were selected as control group.All rats were underwent heart echocardiography check.The left ventricular end-diastolie inner diameter(LVEDD),the left ventricular end-systolic diameter (LVESD),and the left ventricular ejection fraction(LVEF) were caculated.The levels of serum BNP,aspartate aminotransferase(AST),γ-glutamyl (γ-GT) were detected. Results Compared with control group,the LVEF level of the rats in heart failure group was decreased (P<0.01),the BNP level was increased(P<0.01),and the AST and γ-GT levels were significantly increased(P<0.01). When LVEF and BNP were regarded as independent variables,and AST and γ-GT were regarded as the dependent variables,the linear regression analysis was performed;the γ-GT and AST levels were elevated with the decreasing of LVEF level,they had a negative correlation (λ =-0.765,λ=-0.789) (P<0.01);the AST and γ-GT levels were elevated with the increasing of BNP level,and they had a positive correlation (λ=0.793,λ= 0.648)(P<0.01). Conclusion The heart function and liver function of the rats with acute decompensated heart failure are abnormale;the LVEF level is declined,and the BNP,AST and γ-GT levels are increased;the γ-GT and AST levels have negative correlation with LVEF,and the AST and γ-GT levels have positive correlation with BNP.It indicates that the changes of liver function can be used to evaluate the curative effect and prognosis of the patients with heart failure.
Key words: acute decompensated heart failure, isoproterenol, left ventricular end-diastolie inner diameter, left ventricular end-systolic diameter, left ventricular ejection fraction, aspartate aminotransferase,&gamma, -glutamyl, B-type natriuretic peptide
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WU Guo-dong,WANG Su-xia,JI Zhi-yong, ZHANG Shu-yan. Relationship between B-type natriuretic peptide level and liver function of rats with acute heart failure[J].Journal of Jilin University Medicine Edition, 2013, 39(3): 517-520.
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URL: http://xuebao.jlu.edu.cn/yxb/EN/10.7694/jldxyxb20130319
http://xuebao.jlu.edu.cn/yxb/EN/Y2013/V39/I3/517
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