重组人脑利钠肽治疗急性失代偿性心力衰竭安全性的Meta分析

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Meta-analysis on safety of recombinant human brain natriuretic peptide in treatment of acute decompensated heart failure

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doi:10.13481/j.1671-587x.20160426

Abstract:

Objective: To evaluate the security of recombinant human brain natriuretic peptide(rhBNP) in the treatment of acute decompensated heart failure(ADHF),and to provide the basis for its application. Methods: Both foreign language databases including PubMed, The Cochrane Library(Issue 1,2015), EMBase and Chinese databases involving CNKI, VIP and Wanfang Data were searched. Two reviewers independently extracted the data, and assessed the quality;then the Meta-analysis was performed by using RevMan 5.1 software and Stata 12.0 software. Results: A total of 35 randomized controlled trials (RCTs) involving 12 143 patients were included. The results of Meta-analysis showed that compared with control group the 1-month mortality(RR=1.01,95%CI:0.85-1.21,P=0.88), 3-month mortality(RR=0.89,95%CI:0.63-1.27,P=0.53)and 6-month mortality(RR=0.97,95%CI:0.87-1.08,P=0.59) in rhBNP group had no statistical differences; no statistical difference was found in the incidence of side effects(RR=1.01,95%CI:0.71-1.43,P=0.97).The incidence of hypotension in rhBNP group was significantly higher than that in control group(RR=1.42,95%CI:0.99-2.03,P=0.06).Conclusion: Compared with dobutamine, vasodilator drugs and placebo, rhBNP doesn't change the mortality and incidence of adverse reactions of the patients with ADHF, but increases the risk of hypotension. Clinical application of rhBNP should be reasonable and its effectiveness should be exerted sufficiently, meanwhile, as much as possible to avoid hypotension, etc.

Key words: recombinant human brain natriuretic peptide, acute decompensated heart failure, security, Meta-analysis

CLC Number:

R541.6

ZU Dongni, ZHAO Mingyi, DU Wei, ZHAO Weichao, JIA Shubing, YANG Jingyu, XIANG Rongwu. Meta-analysis on safety of recombinant human brain natriuretic peptide in treatment of acute decompensated heart failure[J].Journal of Jilin University Medicine Edition, 2016, 42(04): 768-776.

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