鞣花酸对小鼠酒精性肝损伤的保护作用

doi:10.13481/j.1671-587x.20150514

Abstract

Abstract:

Objective To investigate the protecive effects of ellagic acid on alcoholic liver injury in the mice,and to explore its mechanisms. Methods 50 KM mice were randomly divided into control group,model group,low,medium and high doses of ellagic acid groups (n=10). The mice in control group and model group were intragastricly administed with sodium carboxymethyl cellulose solvent;the mice in ellagic acid groups were administed with 160,320 and 480 mg·kg^-1 ellagic acid daily,respectively.After administrated for 15 d,the liver injury model was induced with 12 mL·kg^-1 50% ethanol.16 h later,all the mice were taken blood from the eyes and killed,and the activities of serum aspartate aminotransferase (AST),alanine aminotransferase (ALT), and triglycerides (TG) levels in serum and activities of liver superoxide dismutase (SOD), glutathione peroxidase(GSH) were determined as well as liver malondialdehyde (MDA) levels in liver tissue. Results Compared with control group,the liver index,the activities of ALT,AST,and the level of TG in serum and the level of MDA in liver tissue of the mice were significantly increased(P<0.05 or P<0.01),and the activities of SOD and GSH in liver tissue were significantly decreased in model group(P<0.05 or P<0.01). Compared with model group,the liver index,the activities of ALT,AST in serum and the level of MDA in liver tissue of the mice were significantly decreased,the activities of SOD in liver tissue were significantly increased in low,medium and high doses of ellagic acid groups(P<0.05 or P<0.01), and the activities of GSH in liver tissue were significantly increased in medium and high dose of ellagic acid groups(P<0.01),and the level of TG in serum were significantly decreased in high dose of ellagic acid group(P<0.05). Conclusion Ellagic acid has the protective effect on alcoholic liver injury in the mice and the most effective dose is 480 mg·kg^-1.

Key words: ellagic acid, alcoholic, liver injury, antioxidant, free radicals

CLC Number:

R931.71

YANG Lina, QIAO Nan, HU Minyu, CHEN Jihua, LIN Qian, ZHOU Guangyu, WEI Wei, ZHU Liufeng. Protective effect of ellagic acid on alcoholic liver injury in mice[J].Journal of Jilin University Medicine Edition, 2015, 41(05): 956-960.

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Protective effect of ellagic acid on alcoholic liver injury in mice

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