药物流产后蜕膜组织中IL-10和IL-12表达水平及其对异常子宫出血的影响

doi:10.13481/j.1671-587x.20160127

Abstract

Abstract:

Objective: To investigate the expressions of IL-10 and IL-12 in deciduas tissue of the women after abortion,to explore the correlation between the expressions levels of IL-10 and IL-12 in decidua tissue and abnormal uterine bleeding after abortion. Methods: The healthy pregnant women required termination with gestational age less than 8 weeks were recruited.The methods of drug abortion or surgical abortion were selected according to the women's own will.The women were divided into surgical abortion by vaccum aspiration group,incomplete mifepristone abortion group and complete mifepristone abortion group(n=20).The immunohistochemistry method and Western blotting method were used to detect the exoressions of IL-10 and IL-12 in decidua tissue of the women in various groups.Results: The results of immunohistochemistry method showed that the positive cells of IL-10 and IL-12 scattered among epithelium,glands and stromal cells.The IL-10 expression levels in decidua tissue in mifepristone abortion groups were significantly lower than that in surgical abortion group (P<0.01),and the IL-10 expression level in complete mifepristone abortion group was significantly lower than that in incomplete mifepristone abortion group(P<0.01).The IL-12 expression levels in decidua tissue in mifepristone abortion groups were significantly higher than that in surgical abortion group (P<0.01),and the IL-12 expression level in complete mifepristone abortion group was significantly lower than that in incomplete mifepristone abortion group(P<0.01).The results of Western blotting method were coincided with the results of immunohistochemistry method. Conclusion: Local decidua tissue is not sensitive to mifepristone,which causes the imbalance of expressions of IL-10 and IL-12,and they can promote the abnormal uterine bleeding after abortion.

Key words: uterine bleeding, interleukin-10, interleukin-12, immune response, immune tolerance

CLC Number:

R364.7

WEI Jinbo, LIU Hui, ZHU Xiaotong, LIU Conghui, QU Yine. Expression levels of IL-10 and IL-12 in decidua tissue and their influence in abnormal uterine bleeding after abortion[J].Journal of Jilin University Medicine Edition, 2016, 42(01): 134-138.

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Expression levels of IL-10 and IL-12 in decidua tissue and their influence in abnormal uterine bleeding after abortion

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