淫羊藿醇提物对高脂血症模型小鼠的降血脂作用及其抗氧化活性

doi:10.13481/j.1671-587x.20170101

Abstract

Abstract:

Objective: To discuss the influence of ethanol from Epimedium brevicornu Maxim(EEBM) in the levels of total cholesterol (TC),triglycerides (TG),low-density lipoprotein-cholesterol (LDL-C),and high-density lipoprotein-cholesterol (HDL-C) of the mice with hyperlipemiad, and to clarify its antioxidant activity.Methods: The antioxidant activity of EEBM was evaluated using ferric-reducing antioxidant power assay and DPPH assay, The hyperlipidemic mouse models were established. The mice were randomly divided into normal control group,model group,positive control group,and low, medium, and high doses of EEBM groups; prophylactic administration and remedial administration were evaluated in this study. At the end of the experiment,the serum levels of TC,TG,LDL-C, and HDL-C were detected.Results: The IC₅₀ of EEBM to DPPH free radical scaveging activity was (35.12±0.48) mg·L^-1 in the in vitro antioxidant assay, and its EC₅₀ to ferric-reducing antioxidant power was (148.35±1.38) mg·L^-1. And no matter prophylactic administration or remedial administration,compared with model group, the levels of serum TC,TG,and LDL-C in different doses of EEBM groups were decreased (P<0.05 or P<0.01),and the HDL-C levels were increased (P<0.01).Conclusion: EEBM can significantly change the plasma lipid levels to near the normal.EEBM has the function of lowering the blood lipid activities in the hyperlipidemia mice.

Key words: levels polysaccharide, antioxidant activity, hyperlipidemia, ethanol from Epimedium brevicornu Maxim

CLC Number:

R285.5

ZHAO Yan, HAN Lingling, HOU Yingying, GUO Shuai, TANG Guosheng, ZHANG Lianxue. Hypolipidemic effect of ethanol from Epimedium brevicornu Maxim on hyperlipidemia of mice and its antioxidant activity[J].Journal of Jilin University Medicine Edition, 2017, 43(01): 1-5.

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Hypolipidemic effect of ethanol from Epimedium brevicornu Maxim on hyperlipidemia of mice and its antioxidant activity

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