[1] IDF DIABETES ATLAS,International Diabetes Federation.http://www.diabetesatlas.org/resources/2017-atlas.html, 2017. [2] Levin PA. Practical combination therapy based on pathophysiology of type 2 diabetes[J].Diabetes Metab Syndr Obes,2016,9:355-369. [3] 孙恒,胡强,金航,等.铁皮石斛化学成分及药理活性研究进展[J].中国实验方剂学杂志,2017,23(11):225-234. [4] 施红,杨奇红,张捷平,等.石斛合剂对高脂高糖加链脲佐菌素造模大鼠的作用及机制[J].中国临床康复,2004,8(6):1102-1104. [5] Sylvester PW. Optimization of the tetrazolium dye (MTT) colorimetric assay for cellular growth and viability[J]. Methods Mol Biol,2011,716:157-168. [6] Rieger AM, Nelson KL, Konowalchuk JD, et al. Modified annexin Ⅴ/propidium iodide apoptosis assay for accurate assessment of cell death[J].J Vis Exp,2011.doi:10.3791/2597. [7] Hirano S. Western blot analysis[J]. Methods Mol Biol,2012,926:87-97. [8] 施红,林求诚,陈国强,等.石斛合剂对2型糖尿病的临床疗效观察[J].中药新药与临床药理,2002,13(6):348-350. [9] 黎同明,邓敏贞.石斛合剂对2型糖尿病模型大鼠的降糖作用及其对胰岛细胞凋亡的影响[J].中药材,2012,35(5):765-769. [10] Doerks T, Copley RR, Schultz J, et al. Systematic identification of novel protein domain families associated with nuclear functions[J]. Genome Res,2002,12(1):47-56. [11] Mosa R, Huang L, Wu Y, et al. Hexarelin, a growth hormone secretagogue, improves lipid metabolic aberrations in nonobese insulin-resistant male MKR mice[J]. Endocrinology,2017,158(10):3174-3187. [12] 程瑞婷,王晨斌,田春雨,等.MIN6细胞损伤模型不同造模方法对比研究[J].华北理工大学学报:医学版,2017,19(4):258-262. [13] Ge Y, Zhang Y, Li R, et al. Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes[J]. Int J Biol Sci,2011,7(5):673-684. [14] Wu J, Hou SS, Wang W, et al. Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus[J]. Genet Mol Res, 2015,14(4):16938-16947. [15] Wang R, Gao H, Xu W, et al. Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice[J]. Gene,2013,516(2):248-254. [16] Ayyar VS, Sukumaran S, DuBois DC, et al. Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver[J]. J Pharmacokinet Pharmacodyn,2018.doi:10.1007/S10928-018-9585-x. [17] Bhatia V, Viswanathan P. Insulin resistance and PPAR insulin sensitizers[J]. Curr Opin Investig Drugs, 2006,7(10):891-897. [18] Botta M, Audano M, Sahebkar A, et al. PPAR Agonists and Metabolic Syndrome:An Established Role?[J]. Int J Mol Sci,2018,19(4):1197. [19] 曹荟哲,哈小琴,李雪雁,等.游离脂肪酸致胰岛素抵抗的分子机制[J].解放军医学杂志,2017,42(1):81-85. [20] Cai Y, Wang Y, Zhi F, et al. The effect of Sanggua drink extract on insulin resistance through the PI3K/AKT signaling pathway[J]. Evid Based Complement Alternat Med,2018,2018:1-9. [21] Jeong JH, Kang EB. Effects of treadmill exercise on PI3K/AKT/GSK-3beta pathway and tau protein in high-fat diet-fed rats[J]. J Exerc Nutrition Biochem, 2018,22(1):9-14. *现在齐鲁制药有限公司工作 |