A total of 24 C57BL/6J mice were selected to establish the cerebral ischemia-reperfusion injury models by the modified Zea-Longa suture method， and they were randomly divided into growth hormone treatment group （cerebral ischemia-reperfusion+growth hormone， SG group， n=12） and control group （cerebral ischemia-reperfusion+saline， SS group， n=12）. A total of 48 h after injury， the mice in SG group were injected subcutaneously with the recombinant human growth hormone at the dose of 1.4 mg·kg^－1·d^－1 for 14 d，and the mice in SS group were injected with saline， and the injection time， dose， location and times were consistent with the mice in SG group. Beam balance test was used to evaluate the motor coordination abilities of the mice before injury， 1 d after injury， and 16 d after injury；screen test was used to evaluate the muscle strengths of the mice， and the cylinder test was used to evaluate the utilization rates of the affected limb of the mice；the expression levels of synapsin1（SYN1） in peri-infarct region of the mice in two groups were detected by Western blotting method 16 d after injury.

The beam balance test results showed that compared with before injury， the scores of motor coordination abilities of the mice in two groups 1 d after injury were decreased（P<0.01）； the scores of motor coordination abilities of the mice in two groups 16 d after injury were higher than those 1 d after injury （P<0.01）， and the score of motor coordination ability of the mice in SG group was higher than that in SS group （P<0.05）. The screen test results showed that compared with before injury， the residence time when grasping the screen upside down of the mice in two groups was significantly shortened 1 d after injury （P<0.01）， and the residence time of the mice in two groups 16 d after injury was longer than that 1 d after injury （P<0.01）； compared with SS group， the residence time when grasping the screen upside down of the mice in SG group was significantly increased （P<0.05）.The cylinder test results showed that the utilization rates of affected limb of the mice in two groups were decreased significantly 1 d after injury （P<0.01）；compared with 1 d affter injury， the utilization rates of affected limb of the mice in two groups were increased 16 d after injury （P<0.01）， and the utilization rate of the mice in SG group was higher than that in SS group （P<0.05）. The Western blotting results showed that the expression level of SYN1 in peri-infarct region of the mice in SG group was significantly higher than that in SS group （P<0.05）.

Recombinant human growth hormone can improve the motor function of the mice with focal cerebral ischemia-reperfusion， and its mechanism may be related to the promoting the expression level of SYN1 in peri-infarct region.