Abstract: Objective To study the clinical efficacy of differential diagnosis between malignant and benign solitary pulmonary nodules (SPNs) with single-location dynamic enhanced computed tomography (CT). Methods Thirty-nine patients were studied with single-location dynamic enhanced CT. Patterns of time-density curve were drawn. Peak height and increment of CT value were calculated. 〖WTFZ〗Results Malignant and benign SPNs showed quite different patterns in time-density curve. Enhanced degree of pulmonary carcinoma ［(41.9±2.8）Hu］was higher than that of the tuberculosis［（11.7±7.85)Hu］, which had significant difference (P<0.01). However, here was no significant difference of enhanced degree between pulmonary inflammatory［（43.6±7.7)Hu］ and pulmonary carcinoma SPNs (P>0.10).But the time-density curve of malignant SPNs tend to achieve rapid enhancement- to-peak attenuation and eventually reached a plateau. Inflammatory SPNs showed gradual enhancement without obvious attenuation. The curve of tuberculosis was placid. Conclusion Single-location dynamic contrast enhanced CT is a non-invasive option and can provide quantitative information about blood flow patterns of SPNs.

Key words: X-ray computed, dynamic contrast enhanced, sarcoidosis, pulmonary, lung neoplasmas.