右美托咪定联合无创通气治疗AECOPD并发肺性脑病患者的临床疗效及安全性评价

doi:10.13481/j.1671-587x.20180523

Abstract

Abstract: Objective:To observe the clinical application of dexmedetomidine(Dex) combined with non-invasive positive pressure ventilation(NIPPV) inthe patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with pulmonary encephalopathy, and to clarify its effectiveness Methods:A total of 80 patients with AECOPD and pulmonary encephalopathy were collected and divided into control group and Dex group according to the random digit table(n=40). The patients in control group were treated with conventional therapy, including antibiotics, phlegm, spasmolysis and NIPPV and so on. The patients in Dex group were treated with Dex based on conventional therapy. The heart rate(HR), blood pressure, arterial partial pressure of oxygen(PaO₂), arterial partial pressure of carbondioxide, the rate of endotracheal intubation,the effective rate of NIPPV and the compliance of NIPPV of the patients in two groups were analyzed before and after treatment.The expectoration capacity,delirium and anxiety of the patients in two groups were evaluated. Results:After conventional treatment, the HR, blood pressure and PaCO₂ in two groups were lower than before treatment, and the PaO₂ was higher than before treatment; the degrees of changes of the above indicators in Dex group were more obvious, the differences were statistically significant (P<0.05). At the same time, the intubation rate of the patients in Dex group was lower than that in control group(P<0.05), and the effective rate of NIPPV was higher than that in control group(P<0.05),and the compliance was increased(P<0.05). The ventilatory function, cough ability, expectoration frequency and expectoration volume of the patients in Dex group were not significantly different from those in control group (P>0.05). The incidene rate of delirium and anxiety score of the patients in Dex group were lower than those in control group (P<0.05). Conclusion:Dex combined with NIPPV is a safe and effective method in the treatment of the patients with AECOPD and pulmonary encephalopathy without obvious adverse effects.

Key words: chronic obstructive pulmonary disease, pulmonary encephalopathy, dexmedetomidine, non-invasive positive pressure ventilation, cough capacity

CLC Number:

R563.8

HOU Hailong, TANG Ying, QU Xinglong, HUA Shucheng. Clinical effect of dexmedetomidine combined with non-invasive positive pressure ventilation in treatment of patients with AECOPD complicated with pulmonary encephalopathy and evaluation on its safety[J].Journal of Jilin University(Medicine Edition), 2018, 44(05): 1014-1019.

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Clinical effect of dexmedetomidine combined with non-invasive positive pressure ventilation in treatment of patients with AECOPD complicated with pulmonary encephalopathy and evaluation on its safety

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