ICU患者深部真菌感染的病原菌分布及耐药性分析

doi:10.13481/j.1671-587x.20170122

Abstract

Abstract:

Objective: To master the distribution and drug resistance of deep fungal infection in the ICU patients,and to provide the basis for diagnosis and treatment of fungal infection in clinic.Methods: The fungi isolated from the ICU patient samples in First Hospital of Jilin University from January 2012 to December 2014 were collected. Retrospective study was used to analyze the fungal distribution and drug resistance.The strains were identified by VITEK-32 system and drug susceptibility test was performed with Fungus 3.Results: A total of 1 563 fungal strains were isolated,in which 6.4%(439/6 852),7.2%(444/6189),9.8%(680/6 919) were isolated from 2012 to 2014. The positive rates of fungal detection we re increased year by year(χ²=55.918,P<0.05).The top four fungi were Candida albicans(49.9%),Candida glabrata(17.5%),Candida tropicalis(11.1%),and Candida krusei(10.1%).The top four samples were sputum(38.4%),urine(18.2%),excrement(15.5%),and drain(6.8%).The four major Candida were all sensitive to 5-flucytosine,the difference was not significant between groups(P>0.05);but they had different resistance to voriconazole,fluconazole,and itraco nazole.Conclusion: The positive rates of fungi are increased every year.The major fungus is Candida albicans,and the major sample is sputum.The common fungi have different resistance to antifungal drugs,and monitoring should be enhanced.

Key words: fungi, Candida, resistance, intensive care unit, infection

CLC Number:

R379

HUANG Yan, CHEN Yukun, JI Xufeng, LI Han. Analysis on distribution of pathogens and drug resistance of deep fungal infection in ICU patients[J].Journal of Jilin University Medicine Edition, 2017, 43(01): 111-114.

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Analysis on distribution of pathogens and drug resistance of deep fungal infection in ICU patients

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