Abstract: Objective: To discuss the influence of Tongfengning Capsule(TFN)in the levels of uricacid(UC),creatinine (Cr) and urea nitrogen(BUN) in mouse serum and the activities of the xanthine oxidase(XOD),adenosine deaminase (ADA) activity in the liver homogenate of the mice with hyperuricemia, and to observe the improvement effect of TFN on the pathological changes of liver tissue and to clarify its mechanisms. Methods: The models of mouse hyperuricemia were induced by yeast extract with potassium oxonate. Seventy mice were divided into blank control group,model group, low(200 mg·kg^-1), medium(400 mg·kg^-1)and high(800 mg·kg^-1) doses of TFN groups, allopurinol positive drug control group(50 mg·kg^-1),Tongfengshu(TFS,600 mg·kg^-1) positive drug control group(n=10). The levels of UC,Cr,BUN in serum and the activities of XOD, ADA in homoggenate were detected and the histopathological changes of the kidney tissue of the mice were measured with HE staining. Results: Compared with blank control group, the levels of serum UC, Cr and BUN of the mice in model group were significantly increased(P<0.01),and the activities of XOD and ADA in liver tissue were also increased(P<0.01). Compared with model group, the levels of serum UC, Cr and BUN of the mice in positive drug control groups and different doses of TFN groups were decreased (P<0.01),and the activities of XOD and ADA in liver tissue were also decreased (P<0.05),especially in high dose of TFN group.Compared with model group,the pathologic changes such as renal glomerulus atrophy, renal interstitial fibrosis and expansion of renal tubule of the mice in positive drug control groups and high dose of TFN group were improved to a certain extent. Conclusion: TFN has improvement effcet on the hyperuricemia in the mice and its mechanism is related to the inhibition of uricogenesis and the promotion of UC excretion.

Key words: Tongfengning Capsule, hyperuricemia, yeast extract, potassium oxonate