Abstract:

Abstract:Objective To explore the inhibitory effects   of  P16 functional oligopeptide on proliferation of mouse C6 glioma cells and human U251 glioma cells cul
tivated in vitro. Methods The C6 cells and U251 cells were treated with  different concentrations of P16 functional oligopeptide (12.5,25.0,50.0 and 100.0 mg·L^-1) for 24,48 and 72 h,the negative control group(without P16 functional oligopeptide) was set up at the same time.The inhibitory rates of proliferation of C6 cells and U251 cells were detected with MTT. Results 12.5,25.0,50.0 and 100.0 mg·L^-1  P16 functional oligopeptide inhibited the proliferation of C6 cells and U251 cells. The inhibitory rates of different doses of  P16 functional oligopeptide were higher than that in negative control group(P＜0.01).The inhibitory rate was increased with the increasing of dose andprolongation of time．Conclusion P16 functional oligopeptide can inhibit the growth of C6 cells and U251 cells.

Key words: P16 functional oligopeptide；glioma；C6 cells；U251 cells;cell proliferation