[1] Satoda M,Takagi S,Ohta K,et al. Differential expression of two cell surface proteins,neuropilin and plexin,in Xenopus olfactory axon subclasses [J]. J Neurosci,1995,15(1Pt2):942-955.[2] Van veldhuizen PJ,Zulfiqar M,Banerjee S,et al.Differential expression of neuropilin-1 in malignant and benign prostatic stromal tissue[J].Oncol Reports,2003,10(5): 1067-1071.[3] Valdembri D,Caswell PT,Anderson KI,et al.Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells [J].PLoS Biol,2009,7(1): e25.[4] Nakamura F,Roth L,Nasarre C, et al.Transmembrane domain interactions control biological functions of neuropilin-1 [J].Mol Biol Cell,2008,19(2):646-654.[5] Nasarre C,Roth M,Jacob L,et al.Peptide-based interference of the transmembrane domain of neuropilin-1 inhibits glioma growth in vivo [J].Oncogene,2010,29(16): 2381-2392.[6] Schuch G,Machluf M,Bartsch G Jr,et al.In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist,soluble neuropilin-1,predicts a role of VEGF in the progression of acute myeloid leukemia in vivo [J].Blood,2002,100(13):4622-4628.[7] He Z,Tessier Lavigne M.Neuropilinis a receptor for the axonal chemorepellent Semaphorin [J].Cell,1997,90(4):739-752.[8] Janssen BJ,Malinauskas T,Weir GA,et al.Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex [J].Nat Struct Mol Biol,2012,19(12):1293-1299.[9] Takahashi T,Fournier A,Nakamura F,et al.Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors [J].Cell,1999,99(1):59-69.[10] Antipenko A,Himanen JP,van Leyen K,et al.Structure of the semaphorin-3A receptor binding module [J].Neuron,2003,39(4):589-598.[11] Soker S,Takashima S,Miao HQ,et al.Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor [J].Cell,1998,92(6):735-745.[12] Poltorak Z,Cohen T,Sivan R,et al.VEGF145,a secreted vascular endothelial growth factor isoform that binds to extracellular matrix [J].J Biol Chem,1997,272(11):7151-7158.[13] Miao HQ,Klagsbrun M.Neuropilin is a mediator of angiogenesis [J].Cancer Metastasis Rev,2000,19(1/2):29-37.[14] Wang L,Zeng H,Wang P,et al.Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration [J].J Biol Chem,2003,278(49):48848-48860.[15] Fuh G,Garcia KC,de Vos AM.The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1 [J].J Biol Chem,2000,275(35): 26690-26695.[16] Prahst C,Héroult M,Lanahan AA,et al.Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1 [J].J Biol Chem,2008,283(37): 25110-25114.[17] Mac Gabhann F,Popel AS.Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1: a computational model [J].Am J Physiol Heart Circ Physiol,2005,288(6):H2851- 2860.[18] Fantin A,Vieira JM,Plein A,et al.NRP1 acts cell autonomously in endothelium o promote tip cell function duringsprouting angiogenesis [J].Blood,2013,121(12):2352-2362.[19] Shintani Y,Takashima S,Asano Y,et al.Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling [J].EMBO J,2006,25(13):3045-3055.[20] Ellis LM.The role of neuropilins in cancer [J].Mol Cancer Ther,2006,5(5):1099-107.[21] Escudero-Esparza A,Martin TA,Douglas-Jones A,et al.PGF isoforms,PLGF-1 and PGF-2 and the PGF receptor,neuropilin,in human breast cancer: prognostic significance [J].Oncol Rep,2010,23(2) : 537-544.[22] Hong TM,Chen YL,Wu YY,et al.Targeting neuropilin 1 as an antitumor strategy in lung cancer [J].Clin Cancer Res,2007,13(16): 4759-4768.[23] Cao Y,Wang L,Nandy D,et al.Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes[J].Cancer Res,2008,68(21): 8667-8672.[24] Miao HQ,Lee P,Lin H,et al.Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression[J].FASEB J,2000,14(15): 2532-2539.[25] Osada H,Tokunaga T,Nishi M,et al.Overexpression of the neuropilin 1 (NRP1) gene correlated with poor prognosis in human glioma[J].Anticancer Res,2004,24(2B): 547-552.[26] Kawakami T,Tokunaga T,Hatanaka H,et al.Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma[J].Cancer,2002,95(10): 2196-2201.[27] Barr MP1,Byrne AM,Duffy AM,et al.A peptide corresponding to the neuropilin-1-binding site on VEGF (165) induces apoptosis of neuropilin-1-expressing breast tumour cells [J].Br J Cancer,2005,92(2):328-333.[28] Klagsbrun M,Takashima S,Mamluk R.The role of neuropilin in vascular and tumor biology [J].Adv Exp Med Biol,2002,51 (5): 33-48.[29] Nasarre P,Kusy S,Constantin B,et al.Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion [J].Neoplasia,2005,7(2):180-189.[30] 董娟聪,张海芹,高 辉,等.NRP1 对非小细胞肺癌放射敏感性的影响 [EB/OL].中国科技论文在线[2014-01-02].http://www.paper.edu.cn/releasepaper/content/201401-96.[31] 潘 燚,李伟雄,李俊铭,等.不同非小细胞肺癌细胞株中DNA-PKcs的表达及其与放射敏感性的关系 [J].癌症,2009,28(7):714-717.[32] 刘宏侠.NRP-1在非小细胞肺癌中的表达及临床意义 [J].实用预防医学,2011,18(10),1491-1493.[33] 陈 赟,刘海燕,尹小祥,等.SEMA3B 基因与辐射相关信号通路的研究进展[J].辐射研究与辐射工艺学报,2010,28(4): 197-200.[34] Brieger J,Schroeder P,Gosepath J,et al.VEGF-subtype specific protection of SCC and HUVECs from radiation induced cell death [J].Int J Mol Med,2005,15(1):145-151.[35] Glinka Y,Mohammed N,Subramaniam V,et al.Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-κB activation and tumor sphere formation [J].Biochem Biophys Res Commun,2012,425 (4):775-780.[36] Riese A,Eilert Y,Meyer Y,et al.Epidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis[J].PLoS One,2012,7(12): e50944.[37] Thewes V,Orso F,Jäger R,et al.Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo-and radiation-sensitivity in breast cancer cells[J].BMC Cancer,2010,10(1): 192.[38] Yang HY,Zhou BP,Hung MC,et al.Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27[J].J Biol Chem,2000,275(32): 24735-24739.[39] Vogelstein B,Lane D,Levine AJ.Surfing the p53 network[J].Nature,2000,408(6810): 307-310.[40] Brieger J,Kattwinkel J,Berres M,et al.Impact of vascular endothelial growth factor release on radiation resistance[J].Oncol Reports,2007,18(6): 1597-1601. |