Abstract:

Objective To detect the chromosome in missed abortion an dead fetus tissues with fluorescence　in situ hybridization(FISH) and  study the relationship between number abnormality of chromosomes and missed abortion,dead fetus.Methods 107 cases  of  missed abortion or dead fetus were detected and  the
 number abnormalities  of 13,16,18,21,22,X,Y chromosomes were detected  by FISH.Results Among 107 cases of samples,the number of useful cases was 99,there were 21 cases of abnormal results,the abnormal ratio was  21.2%.Trisomy of chromosome 21 and 16 had the highest incidence(8/21) among autosomal samples,followed by trisomy of chromosome 18(7/21),22(7/21) and 13(6/21).XXY had the highest incidence(6/21) among sex chromosome abnormalities.There was no significant  difference in the  chromosome abnormalities between different sexes(P>0.05).Conclusion Chromosome abnormality can cause the abmormal development of embryo tissue  in the early and middle pregnancy,and lead to embryo stop growing or cause fetal death;and the occurrence rate has no relationship with sex.So it has clinical guiding significance to make targeted chromosome examination  in early and middle  pregnancy with FISH technique  when the woman  has the history of abnormal pregnancy or   high risk pregnancy.

Key words: missed abortion;dead fetus;chromosome abnormality ;fluorescence in situ hybridization