Abstract: Objective To study the relationship between the level of B-type natriuretic peptide(BNP)  and liver function of rats with  acute decompensated heart failure   and to explore the values of the changes of liver function in evaluation of curative effect and prognosis of the patients with heart failure.Methods 60 male SD rats were chosen and  intraperitoneally injected with isoproterenol for establishment of acute decompensated heart failure models.20 rats were randomly selected from the survival  rats after  successful modeling as heart failure group.And 20 normal rats were selected as control group.All rats were underwent heart echocardiography check.The left ventricular end-diastolie inner diameter（LVEDD）,the left ventricular end-systolic diameter (LVESD),and the left ventricular ejection fraction(LVEF) were caculated.The levels of  serum BNP,aspartate aminotransferase(AST),γ-glutamyl (γ-GT) were detected.  Results Compared with control group,the LVEF level of the  rats in heart failure group was decreased (P<0.01),the   BNP level  was  increased(P<0.01),and the AST and γ-GT levels were significantly increased(P<0.01). When LVEF and BNP were regarded  as independent variables,and  AST and γ-GT were regarded as the dependent variables,the linear regression analysis was performed;the γ-GT and AST levels were  elevated with the decreasing of LVEF level,they had a negative correlation (λ =－0.765,λ=－0.789) (P<0.01);the AST and γ-GT levels were elevated with the increasing of BNP level,and they had a positive correlation (λ=0.793,λ= 0.648)(P<0.01). Conclusion The heart function and liver function of the rats with  acute decompensated heart failure  are abnormale;the LVEF level is declined,and the  BNP,AST and γ-GT levels are increased;the  γ-GT and AST levels have  negative correlation with LVEF,and the AST and γ-GT levels have   positive correlation with BNP.It indicates that the changes of liver function can be used to evaluate the curative effect and prognosis of the patients with heart failure.

Key words: acute decompensated heart failure, isoproterenol, left ventricular end-diastolie inner diameter, left ventricular end-systolic diameter, left ventricular ejection fraction, aspartate aminotransferase,&gamma, -glutamyl, B-type natriuretic peptide