Abstract:

Abstract:Objective  To investigate the expressions of CD44 in normal oral mucosa tissues，paracancerous tissues and oral squamous cell carcinoma( OSCC )tissuses and to provide the basis for the determination of CD44 in gene therapy of OSCC.
Methods The expression of CD44 in 65 cases of OSCC,20 cases of paracancerous tissues and 10 cases of normal oral mucosa tissues were detected by immunohistochemistry method.Results The positive expression rate of CD44 in OSCC tissues was higher than those in normal oral mucosa and paracancerous tissues (P<0.05).The expression rate of CD44 was increased with the decreasing of the  differentiation degree of OSCC.The expression of CD44 was higher in the cases with lymphnode metastasis than that in the cases without lymph node  metastasis(P<0.01).The expression of CD44 in advanced stage group was higher than that in early stage group which were classified by clinical stages(P<0.05).The expression of CD44 was not related to the gender,age of the patients or the length,localization of carcinoma(P>0.05).Conclusion The expression levels of CD44 in normal oral mucosa  tissues,paracancerous tissues and OSCC tissues are different,it indicates that high expression of CD44 may be an important indicator for  judgement  of  malignant degree and prognosis of OSCC.

Key words: CD44；oral squamous cell carcinoma；immunohistochemistry;hematoxylin eosin staining