宁夏回族人群TCF7L2基因rs290487位点多态性与2型糖尿病的关联性分析

doi:10.13481/j.1671-587x.20150237

Abstract

Abstract:

Objective To investigate the association between rs290487 polymorphisms of transcription factor 7 like 2 (TCF7L2) gene and type 2 diabetes mellitus (T2DM) in Ningxia Hui population,and to clarify whether the TCF7L2 gene is the susceptible gene of T2DM.Methods Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method was used to detect the distribution of the geotypic and allelic frequencies of rs290487 site of TCF7L2 gene of the objects,including 111 T2DM patients (T2DM group) and 109 healthy individuals (control group)in Ningxia Hui population. χ² test was used to compare the differences of the allelic frequency and genotypic frequcecy of the objects between two groups.Results Three genotyps TT,CT,and CC were found both in T2DM group and control group; the genotypic frenquencies of rs290487 site of TCF7L2 gene did not deviate from the Hardy-Weinberg equilibrium in two groups (P>0.05); there was no significant difference of the genotypic frequency of rs290487 site between two groups(χ²=5.370,P>0.05);there was no significant difference of the alleclic frequency of rs290487 site between two groups (χ²=0.034,P>0.05).Conclusion The polymorphisms of rs290487 site of TCF7L2 gene has no relationship with T2DM in Ningxia Hui population,and TCF7L2 gene may be not the susceptible gene of T2DM.

Key words: transcription factor 7 like 2, type 2 diabetes mellitus, Ningxia Hui population, single nucleotide polymorphisms

CLC Number:

R593.22

YANG Yi, QI Aiqin, HAO Xiujing, XU Jinrui. Association between rs290487 polymorphisms of TCF7L2 gene and type 2 mellitus diabetes in Ningxia Hui population[J].Journal of Jilin University Medicine Edition, 2015, 41(02): 393-396.

References

[1] Brunetti A,Chiefari E,Foti D. Recent advances in the molecular genetics of type 2 diabetes mellitus [J]. World J Diabetes,2014,5(2):128-140.

[2] Ali O. Genetics of type 2 diabetes[J].World J Diabetes,2013,4(4):114-123.

[3] 张勇,荣海钦,王辉,等. TCF7L2基因rs290487多态性与2型糖尿病相关研究 [J]. 实用糖尿病杂志,2009,5(3):27-29.

[4] Lin L,Yang J,Ding Y,et al. Genetic polymorphisms of TCF7L2 lack influence on risk of the polycystic ovary syndrome-a systemic analysis [J]. Asian Pac J Cancer Prev,2014,15 (7):3331-3333.

[5] Zhang BC,Li WM,Zhu MY,et al. Association of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han Chinese population:a meta-analysis [J]. Gene,2013,512 (1):76-81.

[6] 唐朝泽,吴志香. 2型糖尿病发生机制的研究进展 [J]. 辽宁中医药大学学报,2009,11 (6):69-70.

[7] Palizban A,Nikpour M,Salehi R,et al. Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population [J]. Clin Exper Med,2012,12 (2):115-119.

[8] Barros CM,Araujo-Neto AP,Lopes TR,et al. Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil [J]. Genet Mol Res,2014,13(3):7889-7898.

[9] Hussain H,Ramachandran V,Ravi S,et al. TCF7L2 rs7903146 polymorphism and diabetic nephropathy association is not independent of type 2 diabetes-a study in a south Indian population and meta-analysis [J]. Endokrynol Pol,2014,65(4):298-305.

[10] Wang J,Zhang J,Li L,et al. Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus:a meta-analysis [J]. Braz J Med Biol Res,2013,46(4):382-393.

[11] 朱晖,王佑民,许敏,等. 生物芯片快速检测糖尿病风险基因TCF7L2 rs290487位点[J].安徽医科大学学报,2011,46 (1):20-24.

[12] Chang YC,Chang TJ,Jiang J,et al. Association study of the genetic polymorphisms of the transcription factor7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population [J]. Diabetes,2007,56 (10):2631-2637.

[13] Ren Q,Han XY,Wang F,et al. Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population [J]. Diabetologia,2008,51 (7):1146-1152.

[14] 边澈,李佳,张晓蕾,等. 转录因子7样2基因rs290487-T/C多态性与2型糖尿病患者胰岛素抵抗的相关性 [J].中国生物制品学杂志,2012,25 (8):1017-1020.

[15] 纪红梅,刘巍,边澈,等. TCF7L2基因rs290487多态性与辽宁地区2型糖尿病发病的相关性 [J]. 中国生物制品学杂志,2012,25(6):740-742,753.

[16] 邹云莲,高建梅,徐艳,等. 昆明汉族人群TCF7L2基因rs290487-T/C多态性与2型糖尿病相关性研究[J]. 中国现代医生,2009,47 (29):11-12.

[17] 任倩,韩学尧,萧建中,等. TCF7L2基因rs290487位点多态性与中国汉族人群糖尿病的相关性研究以及荟萃分析[J]. 中华糖尿病杂志,2012,4(s):73-74.

Association between rs290487 polymorphisms of TCF7L2 gene and type 2 mellitus diabetes in Ningxia Hui population

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0

[1]	QI Lu, BAI Wei, YU Weiying, LI Yuanyuan, HUA Wanqing, KOU Changgui. Randomized controlled trials for curative effect of saxagliptin combined with insulin in treatment of patients with type 2 diabetes mellitus: Meta-analysis [J]. Journal of Jilin University(Medicine Edition), 2018, 44(06): 1235-1242.
[2]	QI Bingxue, SUN Yadong. A prospective study on primary prevention of major vascular lesions of type 2 diabetes mellitus patients in Han population in Northeast China [J]. Journal of Jilin University(Medicine Edition), 2018, 44(06): 1243-1248.
[3]	SUN Zhumei, LIANG Weishi, KANG Jiali, MENG Xubing, WANG Jianxing, HAN Shuying. Dynamic pathological characteristics of kidney in db/db mice with type 2 diabetes mellitus [J]. Journal of Jilin University Medicine Edition, 2018, 44(03): 499-503.
[4]	LIU Xiaojie, MEI Tao, MA Hongyan, YE Shandong. Analysis of influencing factors of carotid atherosclerosis plaque formation and stability in simple type 2 diabetic patients [J]. Journal of Jilin University Medicine Edition, 2018, 44(02): 350-355.
[5]	LI Chunhua, GUO Xin, DOU Jing, DING Mingxuan, YAO Yan, ZHANG Yanqiu. Survey analysis on cognitive dysfunction in patients with type 2 diabetes mellitus and its influecing factors [J]. Journal of Jilin University Medicine Edition, 2018, 44(02): 431-437.
[6]	WANG Jianxing, JIANG Yan, WANG Yan, WU Lei, MU Yu, HAN Shuying. Influence of extract from fermented buckwheat flower and leaf in kidney injury in type 2 diabetic db/db mice [J]. Journal of Jilin University Medicine Edition, 2018, 44(01): 95-100.
[7]	GOU Xiangbo, GUO Jing, BAI Jing. Protective effect of total flavones of buckwheat flowers and leaves on myocardial fibrosis of type 2 diabetic ratsand its mechanism [J]. Journal of Jilin University Medicine Edition, 2016, 42(04): 694-698.
[8]	ZAO Hang, WANG XU, LI WEI. Influence of single nucleotide polymorphisms of CDA in prognosis of advanced non-small cell lung cancer patients treated with gemcitabine [J]. Journal of Jilin University Medicine Edition, 2016, 42(02): 316-320.
[9]	TU Peipei, LI Xiaodan, MA Baicheng, ZHANG Yaofang, DUAN Huikun, NI Zaizhong, WANG Haisong, JIANG Pingzhe, LI Miao, WU Ri, LI Minggang. Changes and significance of hepatic histone H3 epigenetic modification in type 2 diabetic mice [J]. Journal of Jilin University Medicine Edition, 2015, 41(04): 756-762.
[10]	WU Xing, JIA Zhifang, YOU Lili, CAO Donghui, WANG Chuan, CAO Xueyuan, JIANG Jing. Influence of single nucleotide polymorphisms of DNMT1 gene in survival of patients with gastric cancer after operation [J]. Journal of Jilin University Medicine Edition, 2015, 41(04): 802-807.
[11]	JIANG Lingling, YANG Xueling, LYU Wei, ZHANG Yue, YIN Yutian, WANG Yuhan, WANG Rui, ZHANG Peng, LI Bo, YAO Yan. Association between HLA-DRB1 gene polymorphisms and essential hypertension [J]. Journal of Jilin University Medicine Edition, 2015, 41(03): 619-624.
[12]	WANG Yuejuan, GAO Lichao, FANG Fang, CUI Weiwei, LIU Ya, GUO Hui. Comparison of progression between diabetic patients with different levels of uric acid and analysis on influencing factors [J]. Journal of Jilin University Medicine Edition, 2015, 41(01): 135-139.
[13]	ZHAO Jin-xiang1,ZHAO Li-yan2,WANG Xiu-ge1,GOU Lin-hua1,NAN Zheng1. Effects of JieDu TongLuo BaoShen capsule on serum adiponectin and expression levels of adiponectin and MCP-1 proteins in kidney tissue of type 2 diabetic rats [J]. Journal of Jilin University Medicine Edition, 2014, 40(01): 65-69.
[14]	GOU Xiang-bo,GUO Jing,WANG Yin-huan,AI Ling-yan,HAN Shu-ying. Protective effect of extract of buckwheat chaff  on myocardial injury of type 2 diabetic rats [J]. Journal of Jilin University Medicine Edition, 2013, 39(6): 1215-1218.
[15]	XU Jin-rui, NA Xiao-fei, YANG Yi. Relevance analysis on polymorphisms of four SNPs of VDR gene and type 2 diabetes mellitus in Ningxia Han population [J]. J4, 2012, 38(5): 985-989.