Abstract:

Objective: To investigate the advantages of autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty in treatment of diabetic foot,and to clarify the clinical effect of this method.Methods: 40 patients with diabetic foot and lower limb blood vessel severe stenosis or occlusion were divided into 2 groups.20 patients treated with autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty were used as combined treatment group,and the other 20 patients treated with autologous bone marrow stem cell transplantation alone were used as single transplation group. The patients in two groups receieved conventional therapy. The limb pain,cold feeling,intermittent claudication,ankle brachial index(ABI)and the number of collateral vessel formation of the patients in two groups were observed before and after treatment,and the curative effects in two groups were compared. Results: Compared with before treatment,the limb pain scores,cold feeling scores and intermittent claudication scores of the patients in two groups after treatment were significantly decreased(P<0.01),and the ABI and the number of collateral vessel formation were significantly increased (P<0.01). The clinical cure rate of the patients in combined treatment group was higher than that in single transplantation group,but the effective rate in combinaed treatment group was lower than that in single transplantation group. Conclusion: Autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty is a safe and effective method for the treatment of diabetic foot.

Key words: diabetic foot, stem cell transplantation, percutaneous transluminal angioplasty