子宫内膜癌组织中hMOF蛋白和mRNA表达及其临床意义

doi:10.13481/j.1671-587x.20160617

Abstract

Abstract:

Objective: To discuss the expressions of hMOF protein and mRMA in endometrial cancer tissue,and to illuminate the possible mechanism of hMOF in the occurrence and development of endometrial cancer.Methods: The PT-PCR and immunohistochemistry methods were used to detect the expressions of hMOF protein and mRNA in 38 cases of endomerial cancer tissues and 20 cases of normal endometrial tissues,and to analyze the relationship between its expression level and the clinical characteristics and prognosis of the patients with endometrial cancer.Results: The immunohistochemistry results showed that the positive expression rate of hMOF protein in endometrial cancer tissue was lower than those in normal endometrial tissue(P=0.037); the positive expression rate of hMOF protein in stage Ⅰ patients was higher than those in stage Ⅱ and Ⅲ-Ⅳ patients(χ²=6.591,P=0.037);the positive exprssion rate of hMOF protein in the patients with poor differentiation was lower than those in the patients with moderate and high differentiation(χ²=7.351,P=0.025).The RT-PCR results showed that the percentage of the patients with expression up-regulation of hMOF mRNA in endometrial carcinoma tissue was remarkly decreased compared with normal endometrial tissue(P=0.003).Conclusion: hMOF protein may participate in the occurrence and development of endometrial cancer,and hMOF protein could be a biomarker for prognosis of endometrial cancer.

Key words: endometrial neoplasms, polymerase chain reaction, immunohistochemistry, acetyltransferases, adenocarcinoma

CLC Number:

R737.33

WEN Aiping, WANG Haijiao, JIN Jingji, CAI Yong, ZHU Jihong, CHEN Lunhua. Expressions of hMOFprotein and mRNA in endometrial cancer tissue and their clinical significances[J].Journal of Jilin University Medicine Edition, 2016, 42(06): 1138-1142.

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Expressions of hMOFprotein and mRNA in endometrial cancer tissue and their clinical significances

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