Journal of Jilin University Medicine Edition ›› 2017, Vol. 43 ›› Issue (01): 125-129.doi: 10.13481/j.1671-587x.20170125

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Therapeutic effect of mosapride citrate on gastrointestinal tract function disorder of patients with Parkinson's syndrome

LIU Yang1, LIU Zhi2, LI Fenge3, KONG Fanli1   

  1. 1. Department of Pathophysiology, School of Basic Medical Sciences, Beihua University, Jilin 132013, China;
    2. Department of Neurology, Center Hospital of Jilin City, Jilin Province, Jilin 132011, China;
    3. Second Department of Neurology, Affiliated Hospital, Beihua University, Jilin 132013, China
  • Received:2016-05-03 Online:2017-01-28 Published:2017-02-08

Abstract:

Objective: To explore the therapeutic effect of mosapride citrate on lower gastrointestinal tract function disorder of the patients with Parkinson's syndrome, and to clarify its mechnism.Methods: A total of 29 patients with Parkinson's syndrome complicated with lower gastrointestinal tract function disorder (20 men,9 women; mean age, 68.7 years) were selected and treated with 15 mg of mosapride citrate 3 times a day,by oral for 3 months. The colonic transit time (CTT) of the patients was detected.and rectoanal videomanometry was used to measure the pressures and capacities in colon of the patients at different periods.Results: The defecation diffculties were improved after treated with mosapride citrate. Compared with before treatment, the mean CTT of the patients after treatment was shorten (P<0.05), expecially in the left colon (P<0.01). Compared with before treatment, mosapride augmented the amplitude in rectal contraction after treatment (P<0.05) and lessened the volume of postdefecation residuals.Conclusion: As a kind of 5-HT4 receptor agonist and 5-HT3 receptor antagonistic agent, mosapride citrate can promote the lower gastrointestinal tract motility and ameliorate constipation in the Parkinson's syndrome patients.

Key words: lower gastrointestinal tract disorder, mosapride citrate, Parkinson's syndrome

CLC Number: 

  • R574.4