DC-CIK免疫治疗对卵巢癌患者凝血功能及D-二聚体水平的影响

doi:10.13481/j.1671-587x.20170124

Abstract

Abstract:

Objective: To investigate the changes of blood coagulation function and D-dimer levels in the ovarian cancer patients before and after dentritic cells-cytokine-induced killer cells (DC-CIK) immunotherapy, and to clarify its clinical significance.Methods: Forty ovarian cancer patients treated with DC-CIK immunotherapy were selected. The indicators of blood coagulation function and the D-dimer levels. 5 d before G-CSF mobilization and 1 month after DC-CIK immunotherapy were detected. The differences in the blood coagulation function and D-dimer levels of the ovarian cancer patients were compared between before and after DC-CIK immunotherapy.Results: The D-dimer level of the ovarian cancer patients was decreased from 1063μg·L^-1 to 485μg·L^-1 after DC/CIK cell reinfusion (P<0.05), and the fibrinogen(FIB) level was decreased by 10%(P<0.05). The changes were more significant in the ovarian cancer patients at Ⅳstage (FIB) and the patients aged over 60 years old. Compared with before treatment,the proption of ovarian cancer patients with normal D-dimer level (<243μg·L^-1) after treatment was increased(P<0.05).Conclusion: DC-CIK immunotherapy can reduce the levels of D-dimer and FIB in the ovarian cancer patients, and also reduce the risk of venous thrombosis.

Key words: dentritic cells-cytokine-induced killer cells, blood coagulation function, D-dimer, ovarian neoplasm, immunotherapy

CLC Number:

R737.31

WANG Ruibin, HE Dongyun, ZOU Jiyan, SHENG Minjia. Influence of DC-CIK immunotherapy in blood coagulation function and D-dimer levels in patients with ovarian cancer[J].Journal of Jilin University Medicine Edition, 2017, 43(01): 120-124.

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Influence of DC-CIK immunotherapy in blood coagulation function and D-dimer levels in patients with ovarian cancer

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