Abstract: Objective: To detect the functional status of major joints in limbs of the patients with moderate hemophilia,and to improve the understanding and management of hemophilia. Methods: A total of 93 patients with moderate hemophilia (FVⅢ:C/FⅨ:C:1%-5%) were divided into seven subgroups according to their ages:<10 years,10-20 years,20-30 years,30-40 years,40-50 years,50-60 years,and > 60 years. The joint involvement rates of patients were observed and the joint function was evaluated using Hemophilia Joint Heath Score (HJHS). Results: Compared with moderate hemophilia group,the difference in the involvement rate of hemophilic arthritis of the patients in severe hemophilia group was not significant(P>0.05).The mean HJHS of the patients in moderate hemophilia group and severe hemophilia group had no statistical difference (P=0.157).In 20-30 years group,the mean HJHS of the patients in severe hemophilia group was higher than that in moderate hemophilia group(Z=-2.127,P=0.033). In 10-20 years and 20-30 years groups,there were statistically significant differences in the HJHS of knee joint between moderate hemophilia group and severe hemophilia group(Z_10-20=-2.710,P_10-20=0.007;Z_20-30=-2.384,P_20-30=0.017).There were no significant differences in the HJHS of the patients in moderate hemophilia group and severe hemophilia group at the different ages (P>0.05). Conclusion: The hemorrhage treatment status of moderate hemophilia patients is poor.The combination of on-demand treatment and preventive treatment can reduce the joint hemorrhage,and guarantee the joint function of hemophilia patients effectively and improve the life quality of the patients.

Key words: on-demand treatment, hemophilia, hemophilic arthritis, moderate hemophilia