Abstract: Objective: To investigate the relationship between the serum levels of coenzyme Q10(CoQ10) of the pregnant women and the neonatal body weight, and to clarify the influence of CoQ10 in the neonatal body weight.Methods: A total of 240 pregnant women were selected.The serum CoQ10 levels of the pregnant women were detected by ELISA.According to the neonatal body weight, the newborn babies were dividied into low body weight group, normal body weight group and marcrosomia group; the maternal serum CoQ10 levels were recorded.According to the seventy-fifth percentile of serum CoQ10, the subjects were divided into CoQ10≥0.85 μmol·L^-1 group and CoQ10<0.85 μmol·L^-1 group. The neonatal body weights were recorded. The correlation between the maternal serum CoQ10 level and the neonatal body weight was analyzed with Spearman correlation analysis method.Results: The serum CoQ10 levels of pregnant women in normal body weight group (0.91 μmol·L^-1±0.41 μmol·L^-1) and low body weight group (0.88 μmol·L^-1±0.38 μmol·L^-1) were higher than that in macrosomia group (0.64 μmol·L^-1±0.23 μmol·L^-1), and the differences were statistically significant (t=7.04,P<0.05;t=7.25,P<0.05); the serum level of CoQ10 of pregnant women was negative correlated with the neonatal birth weight(r=-0.17,P=0.00). The neonatal birth weight in CoQ10≥0.85 μmol·L^-1group(3 209.08 g±320.15 g) was lower than that in CoQ10＜0.85 μmol·L^-1 group(3 823.81 g±189.04 g), the difference was statistically significant (P<0.05).The CoQ10 levels at early pregnancy and late pregnancy and ΔCoQ10 were the factors influencing the neonatal birth weight (P<0.05 or P<0.01);the CoQ10 levels at early pregnancy and late pregnancy and ΔCoQ10 were the protective factors to affect the neonatal birth weight(P<0.05).Conclusion: The level of serum CoQ10 of the pregnant women has effect on the body weights of their newborns

Key words: pregnancy, coenzyme Q10, newborn, body weight