[1] Akkina R.Human immune responses and potential for vaccine assessment in humanized mice[J].Curr Opin Immunol,2013,25(3):403-409. [2] Shultz LD,Brehm MA,Bavari S,et al.Humanized mice as a preclinical tool for infectious disease and biomedical research[J].Ann N Y Acad Sci,2011,1245:50-54. [3] Mosier DE.Human xenograft models for virus infection[J].Virology,2000,271(2):215-219. [4] McCune JM,Namikawa R,Kaneshima H,et al.The SCID-hu mouse:murine model for the analysis of human hematolymphoid differentiation and function[J].Science,1988,241(4873):1632-1639. [5] McCune JM.Development and applications of the SCID-hu mouse model[J].Semin Immunol,1996,8(4):187-196. [6] Jamieson BD,Zack JA.Murine models for HIV disease[J].AIDS,1999,13(Suppl A):S5-11. [7] Akkina R.New generation humanized mice for virus research:comparative aspects and future prospects[J].Virology,2013,435(1):14-28. [8] Lan P,Tonomura N,Shimizu A,et al.Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation[J].Blood,2006,108(2):487-492. [9] Chicha L, Tussiwand R, Traggiai E,et al.Human adaptive immune system Rag2-/- gamma(c)-/- mice[J].Ann N Y Acad Sci, 2005, 1044(1):236-243. [10] Stoddart CA,Maidji E,Galkina SA,et al.Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rr(-/-) (NSG) BLT mice[J].Virology,2011,417(1):154-160. [11] Doulatov S,Notta F,Eppert K,et al.Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development[J].Nat Immunol,2010,11(7):585-593. [12] Baum CM,Weissman IL,Tsukamoto AS,et al.Isolation of a candidate human hematopoietic stem-cell population[J].Proc Natl Acad Sci U S A,1992,89(7):2804-2808. [13] Notta F,Doulatov S,Laurenti E,et al.Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment[J].Science,2011,333(6039):218-221. [14] Pang WW,Price EA,Sahoo D,et al.Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age[J].Proc Natl Acad Sci U S A,2011,108(50):20012-20017. [15] Takizawa H,Schanz U,Manz MG.Ex vivo expansion of hematopoietic stem cells:mission accomplished?[J].Swiss Med Wkly,2011,141:w13316. [16] Boitano AE,Wang J,Romeo R,et al.Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells[J].Science,2010,329(5997):1345-1348. [17] Lapidot T,Sirard C,Vormoor J,et al.A cell initiating human acute myeloid leukaemia after transplantation into SCID mice[J].Nature,1994,367(6464):645-648. [18] Bonnet D,Dick JE.Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell[J].Nat Med,1997,3(7):730-737. [19] Dick JE.Stem cell concepts renew cancer research[J].Blood,2008,112(13):4793-4807. [20] Reya T,Morrison SJ,Clarke MF,et al.Stem cells,cancer,and cancer stem cells[J].Nature,2001,414(6859):105-111. [21] Magee JA,Piskounova E,Morrison SJ.Cancer stem cells:impact,heterogeneity,and uncertainty[J].Cancer Cell,2012,21(3):283-296. [22] Meyer LH,Eckhoff SM,Queudeville M,et al.Early relapse in ALL is identified by time to leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways[J].Cancer Cell,2011,19(2):206-217. [23] Raaijmakers MH,Mukherjee S,Guo S,et al.Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia[J].Nature,2010,464(7290):852-857. [24] Jin L,Hope KJ,Zhai Q,et al.Targeting of CD44 eradicates human acute myeloid leukemic stem cells[J].Nat Med,2006,12(10):1167-1174. [25] Jin L,Lee EM,Ramshaw HS,et al.Monoclonal antibody-mediated targeting of CD123,IL-3 receptor alpha chain,eliminates human acute myeloid leukemic stem cells[J].Cell Stem Cell,2009,5(1):31-42. [26] Kikushige Y,Shima T,Takayanagi S,et al.TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells[J].Cell Stem Cell,2010,7(6):708-717. [27] Majeti R,Chao MP,Alizadeh AA,et al.CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells[J].Cell,2009,138(2):286-299. [28] Saito Y,Uchida N,Tanaka S,et al.Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML[J].Nat Biotechnol,2010,28(3):275-280. [29] McCune J,Kaneshima H,Krowka J,et al.The SCID-hu mouse:a small animal model for HIV infection and pathogenesis[J].Annu Rev Immunol,1991,9:399-429. [30] Namikawa R,Kaneshima H,Lieberman M,et al.Infection of the SCID-hu mouse by HIV-1[J].Science,1988,242(4886):1684-1686. [31] Mosier DE,Gulizia RJ,Baird SM,et al.Human immunodeficiency virus infection of human-PBL-SCID mice[J].Science,1991,251(4995):791-794. [32] Baenziger S,Tussiwand R,Schlaepfer E,et al.Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/- gamma c-/- mice[J].Proc Natl Acad Sci U S A,2006,103(43):15951-15956. [33] Berges BK,Wheat WH, Palmer BE,et al.HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/- gamma c-/- (RAG-hu) mouse model[J].Retrovirology,2006,3:76. [34] Gorantla S,Sneller H,Walters L,et al.Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/- gammac-/- mice[J].J Virol,2007, 81(6):2700-2712. [35] Brainard DM,Seung E,Frahm N,et al.Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice[J].J Virol,2009,83(14):7305-7321. [36] Denton PW,Estes JD,Sun Z,et al.Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice[J].PLoS Med,2008,5(1):e16. [37] Sun Z,Denton PW,Estes JD,et al.Intrarectal transmission,systemic infection,and CD4+ T cell depletion in humanized mice infected with HIV-1[J].J Exp Med,2007,204(4):705-714. [38] Denton PW,García JV.Humanized mouse models of HIV infection[J].AIDS Rev,2011,13(3):135-148. [39] Siu E,Ploss A. Modeling malaria in humanized mice:opportunities and challenges[J].Ann N Y Acad Sci,2015,1342:29-36. [40] Chen Q,Amaladoss A,Ye W,et al.Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells[J].Proc Natl Acad Sci U S A,2014,111(4):1479-1484. [41] Malleret B,Li A,Zhang R,et al.Plasmodium vivax:restricted tropism and rapid remodeling of CD71-positive reticulocytes[J].Blood,2015,125(8):1314-1324. [42] Traggiai E, Chicha L,Mazzucchelli L,et al.Development of a human adaptive immune system in cord blood cell-transplanted mice[J].Science,2004,304(5667):104-107. [43] Strowig T,Gurer C,Ploss A,et al.Priming of protective T cell responses against virus-induced tumors in mice with human immune system components[J].J Exp Med,2009,206(6):1423-1434. [44] Yajima M,Imadome K,Nakagawa A,et al.T cell-mediated control of Epstein-Barr virus infection in humanized mice[J].J Infect Dis,2009,200(10):1611-1615. [45] Gurer C,Strowig T,Brilot F,et al.Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses[J].Blood,2008,112(4):1231-1239. [46] Kwant-Mitchell A,Ashkar AA,Rosenthal KL.Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model[J].J Virol,2009,83(20):10664-10676. [47] Washburn ML,Bility MT,Zhang L,et al.A humanized mouse model to study hepatitis C virus infection,immune response,and liver disease[J].Gastroenterology,2011,140(4):1334-1344. [48] Robinet E,Baumert TF.A first step towards a mouse model for hepatitis C virus infection containing a human immune system[J].J Hepatol,2011,55(3):718-720. [49] Brehm MA,Bortell R,Diiorio P,et al.Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice[J].Diabetes,2010,59(9):2265-2270. [50] O'Boyle G,Fox CR,Walden HR,et al.Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation[J].Proc Natl Acad Sci U S A,2012,109(12):4598-4603. [51] Kalscheuer H,Danzl N,Onoe T,et al.A model for personalized in vivo analysis of human immune responsiveness[J].Sci Transl Med,2012,4(125):3003481. [52] Vesely MD,Kershaw MH,Schreiber RD,et al.Natural innate and adaptive immunity to cancer[J].Annu Rev Immunol,2011,29:235-271. [53] Sharma P, Wagner K,Wolchok JD,et al.Novel cancer immunotherapy agents with survival benefit:recent successes and next steps[J].Nat Rev Cancer,2011,11(11):805-812. [54] Aspord C,Pedroza-Gonzalez A,Gallegos M,et al.Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development[J].J Exp Med,2007,204(5):1037-1047. [55] Pedroza-Gonzalez A,Xu K,Wu TC,et al.Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation[J].J Exp Med,2011,208(3):479-490. [56] White JC,Pawar A,Fu G,et al.TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1[J].Blood Cells Mol Dis,2015,55(4):316-317. [57] Good MF,Hawkes MT,Yanow SK.Humanized mouse models to study cell-mediated immune responses to liver-stage malaria vaccines[J].Trends Parasitol,2015,31(11):583-594. [58] Cui L,Lindner S,Miao J.Modeling malaria in humanized mice:opportunities and challenges[J].Ann N Y Acad Sci,2015,1342(1):29-36. [59] Chen Q,Amaladoss A,Ye W,et al.Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells[J].Proc Natl Acad Sci U S A,2014,111(4):1479-1484. [60] Hu Z,Van Rooijen N,Yang YG.Macrophages prevent human red blood cell reconstitution in immunodeficient mice[J].Blood,2011,118(22):5938-5946. |