关键词:  , 种植牙, 种植体稳定性, 共振频率分析, 糖尿病, 糖化血红蛋白

Abstract: Objective   To explore the  relationship between glycemic control and implant healing
 in the patients with type 2 diabetes mellitus by studying the influence of diff
erent blood sugar levels in  the inflammatory indexes of implants and implant st
ability.Methods 21 patients with type 2 diabetes mellitus(diabetes group) and 10 healthy individuals (control
 group) were selected.40 implants were placed under local anesthesia, blood routine exam
ination was performed before and 24 h after operation,and the amount of inflammatory cells was counted.The glycated hemoglobin (HbAlc) levels
were assayed 8  and 12 weeks after implantation,the mean values were recorded as blood sugar indexes.The implant stability indexes were detected by means of
resonance frequency analysis on weeks 0,2,4,6,8 and 12 after implantation.The maximum decrease in
 stability from baseline and the time for stability level returned to baseline were calculated.
Results The inflammatory cell levels in diabetes group were higher than those in non-diabetic after implantation（P<0.05）,while no difference was found
before implantation（P>0.05）.The implant stabilities were compared according to HbAlc
levels;the patients with  higher HbA1c level had a greater maximum decrease in stability from baseline,while the difference between various groups had statistical significance（P<0.01）.The patients with HbA1c ≥7.6% required a longer time for stability level to returne
 to baseline than the patients with HbA1c ≤7.5%（P<0.01）.Conclusion The inflammatory reaction and implant stability in the patients with type 2 di
abetes mellitus are related to glycemic control.Better control of blood glucose will improve implant healing.

Key words:  , implant, omplant stability, resonance frequency analysis, diabetes mellitus, glycosylated hemoglobin