吉林大学学报(医学版) ›› 2013, Vol. 39 ›› Issue (3): 517-520.doi: 10.7694/jldxyxb20130319

• 基础研究 • 上一篇    下一篇

急性心力衰竭大鼠B型钠尿肽水平与肝功能的关系

武国东1，王素侠1，及志勇1，张舒岩2   

  1. 1.吉林大学第一医院心内科,吉林 长春 130021；2.吉林大学第一医院神经外科，吉林 长春 130021
  • 收稿日期:2013-01-30 出版日期:2013-05-28 发布日期:2013-07-01
  • 通讯作者: 张舒岩（Tel：0431-84808227,E-mail:syzh@yahoo.com.cn） E-mail:syzh@yahoo.com.cn
  • 作者简介:武国东(1971-),男,黑龙江省巴彦县人，主治医师，医学硕士，主要从事冠脉介入方面的研究。 
  • 基金资助:

    吉林省教育厅“十一五”科学技术研究项目资助课题(吉教科合字［2010］D609号)

Relationship between B-type natriuretic peptide level and liver 
function of rats with acute heart failure

WU Guo-dong1，WANG　Su-xia1,JI Zhi-yong1， ZHANG Shu-yan2   

  1. 1.Department of Cardiology,First Hospital,Jilin University,Changchun 130021,China;2.Department of Neurosurgery,First Hospital,Jilin Univerysity,Changchun 130021,China
  • Received:2013-01-30 Online:2013-05-28 Published:2013-07-01

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摘要： 目的:探讨急性失代偿期全心衰竭大鼠B型钠尿肽（BNP）与肝功能的关系，阐明肝功能的变化对评价心力衰竭患者治疗效果和预后的价值。方法:选择雄性健康SD大鼠60只，采用腹腔连续注射异丙肾上腺素方法建立大鼠急性失代偿期全心衰竭模型，成功造模后存活的大鼠中随机选取20 只作为心力衰竭组,另选取20只正常大鼠为对照组。2组大鼠均行心彩检查，测量左室舒张末内径（LVEDD）和收缩末内径（LVESD），计算左室射血分数（LVEF）；检测2组大鼠血清BNP水平、血清天冬氨酸氨基转移酶（AST）和γ-谷氨酰转肽酶（γ-GT）水平。结果:与对照组比较，心力衰竭组大鼠LVEF值显著降低（P<0.01），BNP值明显增高（P<0.01）；血清AST和γ-GT明显升高（P<0.01）。分别以LVEF和BNP为自变量，以AST及γ-GT为因变量进行线性回归分析，γ-GT和AST水平随LVEF的下降而升高，呈负相关关系（λ=－0.765，λ=－0.789，P<0.01）；AST和γ-GT随BNP水平升高而升高，呈正相关关系（λ=0.793，λ=0.648，P<0.01）。结论:急性失代偿期全心衰竭大鼠的心功能与肝功能均异常，LVEF水平下降，BNP、AST和γ-GT 水平升高；BNP与AST、γ-GT呈正相关关系，LVEF与AST、γ-GT呈负相关关系，提示肝功能变化可作为评估心力衰竭患者治疗效果和预后的指标。

关键词: 急性失代偿期全心衰竭, 盐酸异丙肾上腺素, 左心室舒张末内径, 左心室收缩
末内径, 左心室射血分数, 天冬氨酸氨基转移酶, &gamma, -谷氨酰转肽酶, B型钠尿肽

Abstract: Objective To study the relationship between the level of B-type natriuretic peptide(BNP)  and liver function of rats with  acute decompensated heart failure   and to explore the values of the changes of liver function in evaluation of curative effect and prognosis of the patients with heart failure.Methods 60 male SD rats were chosen and  intraperitoneally injected with isoproterenol for establishment of acute decompensated heart failure models.20 rats were randomly selected from the survival  rats after  successful modeling as heart failure group.And 20 normal rats were selected as control group.All rats were underwent heart echocardiography check.The left ventricular end-diastolie inner diameter（LVEDD）,the left ventricular end-systolic diameter (LVESD),and the left ventricular ejection fraction(LVEF) were caculated.The levels of  serum BNP,aspartate aminotransferase(AST),γ-glutamyl (γ-GT) were detected.  Results Compared with control group,the LVEF level of the  rats in heart failure group was decreased (P<0.01),the   BNP level  was  increased(P<0.01),and the AST and γ-GT levels were significantly increased(P<0.01). When LVEF and BNP were regarded  as independent variables,and  AST and γ-GT were regarded as the dependent variables,the linear regression analysis was performed;the γ-GT and AST levels were  elevated with the decreasing of LVEF level,they had a negative correlation (λ =－0.765,λ=－0.789) (P<0.01);the AST and γ-GT levels were elevated with the increasing of BNP level,and they had a positive correlation (λ=0.793,λ= 0.648)(P<0.01). Conclusion The heart function and liver function of the rats with  acute decompensated heart failure  are abnormale;the LVEF level is declined,and the  BNP,AST and γ-GT levels are increased;the  γ-GT and AST levels have  negative correlation with LVEF,and the AST and γ-GT levels have   positive correlation with BNP.It indicates that the changes of liver function can be used to evaluate the curative effect and prognosis of the patients with heart failure.

Key words: acute decompensated heart failure, isoproterenol, left ventricular end-diastolie inner diameter, left ventricular end-systolic diameter, left ventricular ejection fraction, aspartate aminotransferase,&gamma, -glutamyl, B-type natriuretic peptide

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