芪冬颐心口服液对麻醉犬血流动力学及心肌缺血的影响

doi:吉林省科技厅资助课题

芪冬颐心口服液对麻醉犬血流动力学及心肌缺血的影响

王秋静¹，吕文伟¹，路航²，刘芬¹，杨世杰¹，华玉强³，季淑霞³

1. 吉林大学基础医学院机能科学实验中心，吉林长春130021；2. 吉林大学化学院教学中心，吉林长春130021；3. 吉林通化白山药业股份有限公司，吉林通化134000

收稿日期:2002-06-21 修回日期:1900-01-01 出版日期:2004-09-28 发布日期:2004-09-28

Effects of QiDong YiXin on hemodynamics andacute myocardial ischemia in anesthetic dogs

WANG Qiu-jing¹, LＵ Wen-wei¹, LU Hang², LIU Fen¹, YANG Shi-jie¹,HUA Yu-qiang³, JI Shu-xia³

1. Experimental Center of Functional Sciences, School of Basic Medical Sciences, Jilin University,Changchun 130021,China;2.Department of Teaching Center, College of Chemistry,Jilin University, Changchun 130021,China;3.BaiShan Pharmaceutical LimitedCompany of Tonghua City,Jilin Province,Tonghua 134000,China

Received:2002-06-21 Revised:1900-01-01 Online:2004-09-28 Published:2004-09-28

摘要/Abstract

摘要： 目的：观察芪冬颐心口服液（QDYX）对正常犬血流动力学和心肌耗氧量的影响，及对急性心肌梗死犬的影响。方法：采用麻醉开胸犬，测定心脏血流动力学和心肌氧代谢参数，并结扎犬左冠状动脉前降支（LAD）复制急性心肌梗死模型，测定心肌梗死面积及血清酶学变化。结果：1.0、2.0 g•kg^-1 QDYX可降低冠脉阻力，增加冠脉流量，减少心肌耗氧量，缩小心肌梗死面积，降低血清肌酸激酶（CK）及乳酸脱氢酶（LDH）活性。结论：QDYX能降低冠脉阻力，增加冠脉流量，减少心肌耗氧量，对缺血心肌具有保护作用。

关键词: 药物疗法, 急性病, 药物疗法, 芪冬颐心口服液, 犬

Abstract: Objective To observe the influences of QiDong YiXin(QDYX) on hemodynamics and myocardial oxygen consumption, and its protective effects on acute myocardial infarction in anesthetic dogs. Methods The parameters of hemodynamics and myocardial oxygen metabolism were measured in the anaesthetic dogs with thoracotomy. The myocardial infarction size and the changes of the enzymes in serum were determined by using the acute myocardial infarction models with ligation of LAD in the anaesthetic dogs with thoracotomy. Results The coronary resistance and myocardial oxygen consumption were decreased, the myocardial blood flow was increased in dogs treated with QDYX of 1.0 and 2.0 mg•kg^-1. The myocardial infarction size and the activities of serum creatine kinase (CK) and lactic dehydrogenase (LDH) were decreased in acute myocardial infarction dogs treated with QDYX of 1.0 and 2.0 mg•kg^-1. Conclusion QDYX has protective effect on myocardial ischemia through decreasing myocardial oxygen consumption in dogs.

Key words: drug therapy, acute disease, drug therapy, QiDong YiXin , dogs

中图分类号:

R285.5

王秋静，吕文伟，路航，刘芬，杨世杰，华玉强，季淑霞. 芪冬颐心口服液对麻醉犬血流动力学及心肌缺血的影响[J]. J4, 2004, 30(5): 738-741.

WANG Qiu-jing, LＵ Wen-wei, LU Hang, LIU Fen, YANG Shi-jie,HUA Yu-qiang, JI Shu-xia. Effects of QiDong YiXin on hemodynamics andacute myocardial ischemia in anesthetic dogs[J]. J4, 2004, 30(5): 738-741.

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