关键词: 一氧化氮, 血浆纤溶酶原激活物抑制物-1, 阿托伐他汀

Abstract: To investigate the expressions of nitric oxide (NO) and plasminogen activator inhibitor type-1（PAI-1）in rabbit models of atherosclerosis and the interference effect of atorvastatin. Methods Twenty four male Japanese rabbits were divided into 3 groups (8 in each group): high-fat diet group（group A）,high-fat plus atorvastatin group (group B) and normal diet group（group C）.The expressions of NO and PAI-1 were detected with ELISA assay.Plasma lipid was detected with automatic analysis divice. Results The espression of NO in group B was significantly higher than those in groups A and group C (P<0.01); there was no significant difference between groups A and C (P>0.05).The expression of PAI-1 in group B was significantly lower than those in groups A and C,there was no significant difference between groups A and group C (P>0.05).The levels of serum TC in groups A,B,and C were （23.51±10.58）,（14.27±3.51）and（1.36±0.33）mmol•L^-1, respectively; the levels of serum LDL in groups A,B,and C were （21.39±10.00），（14.23±4.01）and（0.72±0.35）mmol•L^-1;there were significant differences between three groups (P<0.05),while TG had no significant difference between three groups (P>0.05). Conclusion High-fat diet has no significant effect on the expressions of NO and PAI-1 in atherosclerosis rabbits .Atorvastatin can increase the expression of NO and decrease the expression of PAI-1,and can inhibit the progression of atherosclerosis.

Key words: nitric oxide , plasminogen activator inhibitor type-1, atorvastatin