关键词: 幽门, 肝炎, 乙型, 慢性, HBV DNA

Abstract: Abstract:Objective To research the role of Helicobacter pylori (Hp) on chronic hepatitis B.Methods The seroprevalence of Hp infection and the quantity and genotyping of HBV DNA in 376 patients with chronic hepatitis B,including chronichepatitis group,cirrhosis group and HBV-related hepatocellular carcinoma (HCC)group,were detected,and compared with control and gastritis groups. Results Hp seropositivities in chronic hepatitis B group (56.2%),cirrhosis group (69.9%),HCC group (75.0%) were higher than that in control group (43.4%) (P<0.01),and had no significant difference with chronic gastritis group (57.9%) (P>0. 05),the Hp seropositivities in cirrhosis and HCC groups were higher than that in chronic hepatitis group (P<0.05).With the different quantities of HBV,Hp seropositivities all increased compared with control group (P<0.01); but there was no significant difference between the different quantities of virus.Hp seropositivities in chronic hepatitis patients with genotype B，C and D were 61.3%,63.3%,and 50.0%,respectively,but there was no significant difference between patients with different HBV genotypes (P>0.05). Conclusion Seroprevalence of antibodies to Hp in patients with chronic hepatitis B increases significantly，and Hp seropositivity increases with the pathological changes of chronic hepatitis B.

Key words: hepatitis B, chronic, HBV DNA