关键词: 癫痫, 心肌, ERK1, 海人藻酸

Abstract: Abstract:Objective To study the effect of candesartan on the ERK1/2 protein expression in myocardium of epilepsy rats induced by kainic acid(KA) and its mechanism.Methods 105 male Wistar rats were divided into: control g₁₈₀roup（A）;epilepsy groups(B_1-5);candesartan groups(C);1-5 meaned 0，0.5，2，4，6 h after epilepsy,respectively.Epilepsy rat models were made by injecting KA into amygdale under stereotactic instrument.The ERK1/2 protein expression in various groups were tested with immunohistological method.Results Compared with control group,the protein expressions of ERK1/2 increased significantly in the 0.5 h groups of B and C （P<0.05）,and attained their peaks respectively in 2 h groups of B and C（P<0.01）,then decreased gradually in 6 h groups of B and C（P>0.05）.The differences in the level of ERK1/2 protein expression between B and C groups were significant（P<0.05）.Conclusion The protein expression of ERK1/2 in rat myocardium increases after epilepsy in a short time;candesartan can decrease the protein expression of ERK1/2 in the myocardium of epilepsy rats.

Key words: epilepsy, myocardium, ERK1, kainic acid