吉林大学学报(医学版)

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AT1R基因A1166C多态性与新疆维吾尔族人群原发性高血压的关系

湛文博1，阿衣古丽.玉努斯2,丁 玮3， 库热西.玉努斯1   

  1. 1.新疆医科大学基础医学院生物化学与分子生物学教研室，新疆 乌鲁木齐 830054；
    2.新疆医科大学第二附属医院药剂科，新疆 乌鲁木齐 830028；3. 新疆医科大学第一附属医院药剂科，新疆 乌鲁木齐 830054
  • 收稿日期:2013-06-08 出版日期:2014-01-28 发布日期:2014-01-25
  • 通讯作者: 阿衣古丽.玉努斯（Tel:0991-4362703， E-mail：aygul8824@sina.com） E-mail:aygul8824@sina.com
  • 作者简介:湛文博(1988-)，女，重庆市人，在读医学硕士，主要从事维吾尔医药与分子生物学研究。
  • 基金资助:

    新疆医科大学地方病分子生物学重点实验室开放课题基金资助课题(XJDX0208-2010-04)

Association between AT1R gene A1166C polymorphism  and essential
 hypertension of Xinjiang Uygur nationality

ZHAN Wen-bo1,Ayigulio.Yunus2，DING Wei3，Kurexio.Yunus1   

  1. 1.Department of Biochemistry and Molecular Biology,School of Basic Medical
     Sciences,Xinjiang Medical University,Urumqi 830054,China；2.Department of Pharmacy,Second
    Affiliated Hospital,Xinjiang Medical University,Urumqi  830028,China；3.Department of  Pharmacy,
    Frist Affiliated Hospital,Xinjiang Medical University,Urumqi 830054,China
  • Received:2013-06-08 Online:2014-01-28 Published:2014-01-25

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摘要：

目的：探讨血管紧张素Ⅱ1型受体(AT1R)基因A1166C多态性与维吾尔族人群原发性高血压
(EH)的关系，阐述AT1R基因A1166C在EH中的作用机制。方法：收集EH组167例、对照组469例、共
636例维吾尔族人群血液样本，采用聚合酶链式反应-限制性片段长度多态性技术（PCR-RFLP）对AT1R基因A1166C进行多态性检测，分析AA、AC和CC 3种基因型以及该位点A、C不同等位基因频率在EH组和对照组中的分布。结果：EH组AC+CC基因型和C等位基因频率明显高于对照
组，差异有统计学意义（χ2=10.179 ，P=0.001）；AC+CC基因型人群患EH的危险度是AA基因型人群的1.6倍（OR=1.612，95%CI:1.191~2.183）。结论：AT1R基因A1166C多态性与维吾尔族EH的发病可能存在一定关联。
［关键词］［中图分类号］

关键词:  , 原发性高血压, 血管紧张素Ⅱ1型受体, 基因多态性, 维吾尔族

Abstract:

Objective To investigate the association between angiotensin Ⅱ type 1 receptor (AT1R) gene A1166C polymorphism and essential hypertension (
EH) in Uygur nationality and to clarify the action mechanism of AT1R gene A1166C in the occ
urrence of EH.Methods 636 cases of Uyghur population blood samples including 167 cases of EH group and 469 cases of control group were collected.
Then polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP )method was adopted to examine the AT1R gene A1166C polymorphism.The distribution of AA,AC and CC genotypes and the different frequencies of the points A,C in EH and  control groups were analyzed.
Results The AC+CC genotype and C allele frequency in EH group were significantly higher than those in control group,the difference was statistically significant（χ2=10.179 ，P=0.001）;the  risk of EH of the people with AC+CC genotypes was 1.6（OR=1.612，95%CL:1.191-2.183）times than that of the people with AA genotype.Conclusion There might be some relationship between AT1R gene A1166C polymorphism and the EH in Uighur population.

Key words: essential hypertension, gene polymorphism, angiotensionⅡtype 1 receptor, Uygur nationality

中图分类号: 

  • R544.1 
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