吉林大学学报(医学版) ›› 2017, Vol. 43 ›› Issue (05): 967-974.doi: 10.13481/j.1671-587x.20170521

• 临床研究 • 上一篇    下一篇

口腔扁平苔藓与白色念珠菌感染关联性的Meta分析

姚亚男, 姚华, 闫朵朵, 吕科佳, 龚励军, 汪国华   

  1. 浙江大学医学院附属第一医院口腔内科, 浙江 杭州 310001
  • 收稿日期:2017-01-15 出版日期:2017-09-28 发布日期:2017-09-29
  • 通讯作者: 姚华,主任医师,硕士研究生导师(Tel:0571-87236338,E-mail:yaohuauk@hotmail.com) E-mail:yaohuauk@hotmail.com
  • 作者简介:姚亚男(1987-),女,内蒙古自治区兴安盟人,住院医师,口腔医学硕士,主要从事口腔黏膜病的病因、诊断以及治疗相关的基础和临床方面的研究。
  • 基金资助:
    国家自然科学基金资助课题(81101660);国家卫生计生委公益性行业科研专项资助课题(201502018);浙江省科技厅自然科学研究基金资助课题(LY14H140001,LY14H140003)

Meta-analysis on correlation between oral lichen planus and Candida albicans infection

YAO Yanan, YAO Hua, YAN Duoduo, LYU Kejia, GONG Lijun, WANG Guohua   

  1. Department of Oral Medicine, First Affiliated Hospital, School of Medical Sciences, Zhejiang University, Hangzhou 310001, China
  • Received:2017-01-15 Online:2017-09-28 Published:2017-09-29

摘要: 目的:采用Meta分析方法评价口腔扁平苔藓(OLP)与白色念珠菌感染的关联性,为OLP的抗真菌治疗提供依据。方法:计算机检索PubMed数据库、EMBase数据库、Medline数据库、Cochrane图书馆、中国知网数据库(CNKI)、中文科技期刊数据库(VIP)和万方数字化期刊库,检索从建库至2016年12月30日所有相关文献。由2位研究者按照纳入和排除标准筛选文献、提取资料并评价质量后,采用RevMan 5.3及Stata12.0软件进行Meta分析,计算优势比(OR)和95%可信区间(95% CI)以评价关联性,采用漏斗图及Egger's法评估文献的发表偏倚。结果:本组共纳入13篇病例对照研究,其中OLP患者1073例,正常对照者766名。OLP患者白色念珠菌检出率明显高出对照组(OR合并=2.30,95% CI:1.60~3.31,P < 0.01)。其中7篇研究对OLP患者进行临床分型,糜烂型OLP(E-OLP)患者白色念珠菌感染风险明显升高(OR=10.12,95% CI:4.05~25.28,P < 0.01)。结论:OLP与白色念珠菌感染有关,这一关联性在EA-OLP患者中尤为明显。

关键词: 病例对照研究, 口腔扁平苔藓, 白色念珠菌, Meta分析

Abstract: Objective: To evaluate the association of oral lichen planus(OLP) with Candida albicans infection by Meta-analysis, and to provide basis for the antifungal treatment of OLP. Methods: Bibliographic searches were conducted in PubMed, EMBase, Medline, The Cochrane Library, CNKI,VIP, and Wanfang databases from inception to December 30 in 2016. The literatures were screened according to the inclusion and exclusion criteria by two reviewers independently, the methodology quality was evaluated after data abstraction, and then the RevMan 5.3 and Stata 12.0 software were used for Meta-analysis to calculate the crude odd ration (OR) and 95% confidence intervals (95% CI). Funnel plot and Egger's methods were used for the evaluation on the publication bias of papers. Results: Thirteen trials were included in this study. Collectively, 1 073 OLP patients and 766 controls were available for analysis. The detection rate of Candida albicans in the OLP patients was significantly higher than that in healthy controls (OR:2.30, 95% CI:1.60-3.31, P<0.01). Seven studies of these included literatures were performed on clinical typing of the OLP patients, and the risk of Candida albicans infection in the patients with erosive-atrophic OLP (E-OLP) was significantly increased(OR=10.12,95%CI:4.05-25.28,P<0.01). Conclusion: OLP has a clear association with Candida albicans infection, and this association is particularly significant in the E-OLP patients.

Key words: oral lichen planus, Candida albicans, Meta-analysis, case-control study

中图分类号: 

  • R781.05