槐杞黄颗粒辅助治疗非急性发作期哮喘患儿的疗效评价

doi:10.13481/j.1671-587x.20180326

摘要/Abstract

摘要： 目的：探讨槐杞黄颗粒辅助治疗非急性发作期哮喘患儿的疗效及其对机体免疫功能指标的影响。方法：将180例非急性发作期哮喘患儿分成常规治疗组（88例）和槐杞黄颗粒治疗组（92例）。常规治疗组患儿采用口服孟鲁司特钠和雾化吸入糖皮质激素治疗，槐杞黄颗粒治疗组患儿在常规治疗基础上联合口服槐杞黄颗粒。检测2组患儿哮喘发作程度指标、中医症候指标、血液免疫功能指标和肺功能指标。结果：治疗前2组患儿病情程度比较差异无统计学意义（P>0.05）。治疗后，与常规治疗后组比较，槐杞黄颗粒治疗组患儿哮喘急性发作程度评分降低（P<0.05）。治疗后，与常规治疗组比较，槐杞黄颗粒治疗组患儿便干/便溏、低热、咳嗽咯痰、神疲纳呆及舌苔白临床症状评分降低（P<0.01），盗汗及口干喜饮评分降低（P<0.05）。治疗后，与常规治疗组比较，槐杞黄颗粒组患儿免疫球蛋白（血清IgA、IgG及IgM）水平明显升高（P<0.05）。治疗后，与常规治疗组比较，槐杞黄颗粒治疗组患儿T细胞、Th细胞及NK细胞百分率升高（P<0.05），B细胞百分率降低（P<0.05）。2组患儿血清Ts细胞百分率比较差异无统计学意义（P>0.05）。治疗后，槐杞黄颗粒治疗组患儿呼气流量峰值（PEF）、第1秒用力呼气肺活量（FEV1）/用力潮气量（FVC）比值高于常规治疗组（P<0.05），但2组患儿FEV1比较差异无统计学意义（P>0.05）。结论：常规治疗基础上联合口服槐杞黄颗粒可以减轻非急性发作期哮喘患儿的病情，改善患儿中医证候和免疫功能。

关键词: 槐杞黄颗粒, 儿童, 哮喘, 中医证候, 免疫调节

Abstract: Objective: To explore the efficacy of Huaiqihuang Granules in the treatment of the children with asthma at non-acute attack stage and its effect on the immune function indexes of body. Methods: A total of 180 children with asthma at non-acute attack stage were divided into Huaiqihuang Granules treatment group (n=92,treated with traditional Chinese medicine Huaiqihuang Granules along with oral montelukast and inhaled corticosteroid,ICS+MK+Hgroup) and routine treatment group(n=88,only given oral montelukast and inhaled corticosteroid,ICS+MK group).The indexes of asthma attack degrees,traditional Chinese medicine (TCM) syndrome indexes, blood immune function indexes and pulmonary function indexes of the children in two groups were detected. Results: There was no difference in the disease degrees of the children between two groups before treatment(P>0.05).Compared with routine treatment group,the score of acute attack of asthma of the children in Huaihuang Granules treatment group was decreased after treatment(P<0.05).Compared with routine treatment group,the scores of dry/loose stools,low-grade fever,cough/expectoration, spiritlessness/anorexia and white tongue fur of the children in Huaiqihuang Granules treatment group were significantly decreased (P<0.01),and the scores of perspire during sleep and dry mouth with desire for drinking were decreased(P<0.05).Compared with routine treatment group,the levels of immunoglobulins (serum lgA,lgG and lgM) of the children in Huaiqihuang Granules treatment group were increased after treatment(P<0.05)Compared with routine treatment group,the percentages of T cells,Th cells and NK cells of the children in Huaiqihuang Granules treatment group were increased(P<0.05),the percentage of B cells was decreased(P<0.05),and there was no difference in the percentages of serum Ts cells of the children between two groups(P>0.05).Compared with routine treatment group,the peak expiratory flow (PEF) and the ratio value of forced expiratory volume in the first second/forced vital capacity(FEV1/FVC) of the children in Huaiqihuang Granules treatment group were increased (P<0.05),but there was no difference in FEV1 of the children between two groups(P>0.05). Conclusion: On the basis of routine treatment,Huaiqihuang Granules can reduce the condition of children with asthma at non-acute attack stage and improve the TCM syndrome and immune function.

Key words: Huaiqihuang Granules, asthma, children, immunoregulation, traditional Chinese medicine syndrome

中图分类号:

R725.6

邹飞, 程志华, 张玉影, 马可. 槐杞黄颗粒辅助治疗非急性发作期哮喘患儿的疗效评价[J]. 吉林大学学报(医学版), 2018, 44(03): 597-603.

ZOU Fei, CHENG Zhihua, ZHANG Yuying, MA Ke. Evaluation on efficacy of Huaiqihuang granules in treatment of children with asthma at non-acute attack stage[J]. Journal of Jilin University Medicine Edition, 2018, 44(03): 597-603.

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