[1] FRICKER M, DEANE A, HANSBRO P M. Animal models of chronic obstructive pulmonary disease[J]. Expert Opin Drug Discov, 2014, 9(6):629-645. [2] LI DD, ZHANG L, ZHOU JH, et al. Cigarette smoke extract exposure induces EGFR-TKI resistance in EGFR-mutated NSCLC via mediating Src activation and EMT[J]. Lung Cancer, 2016, 93:35-42. [3] SOHAL S S. Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD)[J]. Respir Investig, 2017, 55(2):104-113. [4] LAI TT, LI YY, CHEN M, et al. Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial-mesenchymal transition[J]. Lab Invest, 2018, 98(9):1159-1169. [5] GUAN SB, XU WG, HAN FF, et al. Ginsenoside Rg1 attenuates cigarette smoke-induced pulmonary epithelial-mesenchymal transition via inhibition of the TGF-β1/Smad pathway[J]. Biomed Res Int, 2017, 2017:7171404. [6] LEE K H, LEE C H, JEONG J, et al. Neutrophil elastase differentially regulates interleukin 8(IL-8) and vascular endothelial growth factor (VEGF) production by cigarette smoke extract[J]. J Biol Chem, 2015, 290(47):28438-28445. [7] HE Z H, CHEN P, CHEN Y, et al. Comparison between cigarette smoke-induced emphysema and cigarette smoke extract-induced emphysema[J]. Tob Induc Dis, 2015, 13(1):6. [8] 慢性阻塞性肺疾病急性加重(AECOPD)诊治专家组. 慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2017年更新版)[J]. 国际呼吸杂志, 2017, 37(14):1041-1057. [9] CHURG A,COSIO M,WRIGHT J L.Mechanisms of cigarette smoke-induced COPD:insights from animal models[J].Am J Physiol Lung Cell Mol Physiol, 2008, 294(4):L612-L631. [10] KIRKHAM S, KOLSUM U, ROUSSEAU K, et al. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2008, 178(10):1033-1039. [11] PAPAGEORGIS P. TGFβ signaling in tumor initiation, epithelial-to-mesenchymal transition, and metastasis[J].J Oncol, 2015,2015:587193. [12] ZHANG HQ, LIU HL, BOROK Z, et al. Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation[J]. Free Radic Biol Med, 2012, 52(8):1437-1442. [13] CHECA M, HAGOOD J S, VELAZQUEZ-CRUZ R, et al. Cigarette smoke enhances the expression of profibrotic molecules in alveolar epithelial cells[J]. PLoS One, 2016, 11(3):e0150383. [14] LIU M, ZHOU CZ, ZHENG J. Cigarette smoking impairs the response of EGFR-TKIs therapy in lung adenocarcinoma patients by promoting EGFR signaling and epithelial-mesenchymal transition[J]. Am J Transl Res, 2015, 7(10):2026-2035. |