[1] 王建军, 杨秀红, 邓巍, 等.小鼠止血带休克后肾组织ACE/ACE2表达变化及意义[J].中国病理生理杂志, 2011, 27(12):2399-2402. [2] 王建辉, 张伟, 刘燕, 等. 小鼠肢体缺血再灌注后肾组织AT1和Mas受体蛋白差异性表达与肾损伤的关系[J]. 解放军医学杂志, 2016, 41(3):184-188. [3] DASGUPTA C, ZHANG L B.Angiotensin Ⅱ receptors and drug discovery in cardiovascular disease[J]. Drug Discov Today, 2011, 16(1/2):22-34. [4] FOUREAUX G, NOGUEIRA J C, NOGUEIRA B S, et al. antiglaucomatous effects of the activation of intrinsic angiotensin-converting enzyme 2[J]. Invest Ophthalmol Vis Sci,2013,54(6):4296-4306. [5] MECCA A P,REGENHARDT R W, ÓCONNOR T, et al. Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke[J]. Exp Physiol, 2011, 96(10):1084-1096. [6] KAMEL A S, ABDELKADER N F, ABD EL-RAHMAN S S, et al. Stimulation of ACE2/ANG(1-7)/mas axis by diminazene ameliorates Alzheimer's disease in the D-galactose-ovariectomized rat model:Role of PI3K/Akt pathway[J]. Mol Neurobiol, 2018,55(10):8188-8202. [7] QI Y F,ZHANG J, COLE-JEFFREY C T, et al. Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology[J]. Hypertension, 2013, 62(4):746-752. [8] BADAE N M, EL NAGGAR A S, EL SAYED S M, et al. Is the cardioprotective effect of the ACE2 activator diminazene aceturate more potent than the ACE inhibitor enalapril on acute myocardial infarction in rats?[J]. Can J Physiol Pharmacol, 2019, 97(7):638-646. [9] CHEN J J, CUI L Q, YUAN J L, et al. Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity[J]. Mol Med Rep, 2017,16(4):4791-4796. [10] RAJAPAKSHA I G, MAK K Y,HUANG P,et al. The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice[J].Sci Rep, 2018, 8(1):10175. [11] LI S M, WANG X Y, LIU F, et al. ACE2 agonist DIZE alleviates lung injury induced by limb ischemia-reperfusion in mice[J]. Sheng Li Xue Bao, 2018,70(2):175-183. [12] MALEK M, NEMATBAKHSH M.The preventive effects of diminazene aceturate in renal ischemia/reperfusion injury in male and female rats[J]. Adv Prev Med, 2014,2014:740647. [13] FRAGA-SILVA R A, COSTA-FRAGA F P, MONTECUCCO F, et al. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury[J]. J Sex Med, 2015, 12(2):289-302. [14] MALEK V, SHARMA N, SANKRITYAYAN H, et al. Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy[J]. Life Sci, 2019,221:159-167. [15] GORU S K, KADAKOL A, MALEK V, et al. Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes[J]. Br J Pharmacol,2017,174(18):3118-3130. [16] KANGUSSU L M, DE ALMEIDA T C S, PRESTES T R R, et al. Beneficial effects of the angiotensin-converting enzyme 2 activator dize in renovascular hypertension[J]. Protein Pept Lett, 2019,26(7):527-531. [17] TAO L,QIU Y,FU X, et al. Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium[J]. J Neuroinflammat,2016, 13:35. [18] CAO X,YANG F Y,SHI T T, et al. Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis activates Akt signaling to ameliorate hepatic steatosis[J]. Sci Rep,2016,6:21592. [19] BRUCE E B, SAKARYA Y, KIRICHENKO N, et al. ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats[J]. Exp Gerontol, 2018,111:133-140. [20] RAFFAI G, KHANG G, VANHOUTTE P M. Angiotensin-(1-7) augments endothelium-dependent relaxations of porcine coronary arteries to bradykinin by inhibiting angiotensin-converting enzyme 1[J].J Cardiovasc Pharmacol, 2014, 63(5):453-460. [21] YANG X H,WANG Y H,WANG J J,et al. Role of angiotensin-converting enzyme (ACE and ACE2) imbalance on tourniquet-induced remote kidney injury in a mouse hindlimb ischemia-reperfusion model[J]. Peptides,2012,36(1):60-70. |