A total of 315 patients with coronary heart disease who were first admitted to hospital were investigated by using the basic information questionnaire， General Anxiety Disorder-7， Self-Esteem Scale and Perceived Social Support Scale in the study. A total of 305 valid questionnaires were obtained. The influencing factors related to anxiety of the patients were compared between two groups and multiple groups with the method of t-test and single factor analysis of variance.Pearson correlation was used to analyze the correlations between self-esteem， perceived social support and anxiety. Stepwise regression analysis was used to test the mediating effect.

The anxiety level of female in the patients with coronary heart disease was higher than that of male （t=9.664，P<0.01）. The anxiety levels of the patients with different education levels were statistically significant （F=3.146，P<0.05）， and the anxiety level of the illiterate patients was the highest. The anxiety levels of the patients with different marital status were statistically significant（F=9.113，P<0.01）， and the anxiety level of widowed patients was the highest. The anxiety level of the patients with sleep disorders was higher than that of the patients without sleep disorders （t=19.961， P<0.01）. The anxiety level of the patients with alcohol addiction was higher than that of the patients without alcohol addiction （t=10.462， P<0.01）. Self-esteem was positively correlated with perceived social support （r=0.251， P<0.01）， self-esteem was negatively correlated with anxiety （r=－0.173， P<0.01）， and perceived social support was negatively correlated with anxiety （r=－0.187， P<0.01）. Self-esteem could directly predict anxiety （β=－0.224， P<0.01）， and perceived social support played a partial mediating role between self-esteem and anxiety（β=－0.224， P<0.01；β=－0.070， P<0.05）.

Anxiety problems are prominent in the female， illiterate， widowed， alcohol addiction and sleep-disordered patients with coronary heart disease. Low self-esteem and poor perceived social support levels are the predictors of anxiety，and perceived social support plays a partial mediating role between self-esteem and anxiety.