关键词: 药物疗法, 肿瘤, 鳞状细胞, 药物疗法, Ki-67, 核分裂数

Abstract: Objective To evaluate the efficacy of neoadjuvant chemotherapy (NAC) with nedaplatin, ifosfamide and peplomycin (SIP) for patients with locally advanced squamous cell carcinoma of cervix, and to determine whether or not the mitotic index and the Ki-67 labeling index (LI) obtained from biopsy specimens were useful as predictors of NAC response. Methods Twelve cases (stage Ib:3 and II:9) of cervical carcinoma with more than 4 cm in diameter were treated with 1 to 2 courses of SIP therapy followed by surgery. The response to SIP was measured by magnetic resonance imaging (MRI).　The relationship of response and serum SCC, and the changes of mitotic index (MI) and the Ki-67 LI in the biopsy specimens were investiged before and after SIP therapy. Results Seven cases resulted in partial response (PR) and 5 cases did not change (NC), the effective rate was 58.8%. In cases with PR, tumor size reduced markedly after the first course of SIP and serum SCC decreased. MI values in PR cases decreased, and Ki-67 LI was unchanged. On the other hand, in NC cases, MI values did not decrease and Ki-67 LI tended to increase. Conclusion NAC with nedaplatin, ifosfamide and peplomycin was effective for patients with locally advanced squamous cell carcinoma of cervix. Alterations of MRI, serum SCC, MI and Ki-67 LI can be predictors for NAC.

Key words: drug therapy, neoplasms, squamous cell, drug therapy, Ki-67, mitotic index