低剂量博来霉素A5促进荷瘤小鼠化疗效果及其机制探讨

doi:国家自然科学基金资助课题

低剂量博来霉素A₅促进荷瘤小鼠化疗效果及其机制探讨

朴春姬¹，吕鹏²，张海英¹，孙晓玲^1*，王献理¹

1.吉林大学放射医学研究所，吉林长春 130021；2. 长春市铁路医院矫形外科，吉林长春 130051

收稿日期:2003-03-26 修回日期:1900-01-01 出版日期:2004-05-28 发布日期:2004-05-28
通讯作者: 孙晓玲

Antitumor effect of low dose BLMA₅ and its mechanisms

PIAO Chun-ji¹, LU Peng², ZHANG Hai-ying¹, SUN Xiao-ling^1*, WANG Xian-li¹

1.Institute of Radiation Medicine, Jilin University, Changchun 130021,China;2.Department of Orthopedics, Changchun Railway Hospital, Changchun 130051, China

Received:2003-03-26 Revised:1900-01-01 Online:2004-05-28 Published:2004-05-28
Contact: SUN Xiao-ling

摘要/Abstract

摘要： 目的:研究低剂量博来霉素 A₅(BLMA₅,0.08 mg•kg^-1)诱导的适应性反应对皮下接种S180肉瘤的昆明种小鼠模型常规化疗效果的影响及其机制。方法:荷瘤小鼠化疗前预先给予低剂量BLMA₅(D₁)处理，观察肿瘤生长的动态, 制备小鼠骨髓细胞染色体标本及测定肝组织自由基活性。结果:荷瘤小鼠化疗前预先给予D₁处理可使肿瘤生长明显减慢(P<0.05~0.001)，骨髓细胞染色体畸变减轻(P<0.01)，肝脏SOD活性提高(P<0.05)，GSH-Px活性也有增高趋势，且MDA含量降低(P< 0.01)。结论: 低剂量BLMA₅提高化疗效果的机制可能与改善机体抗氧化能力及提高自由基产物的清除能力有关。

关键词: 适应性反应, 抗肿瘤联合化疗方案, 染色体畸变, 自由基

Abstract: Objective To study the common chemotherapy effect and its mechanisms of the adaptive response induced by low dose BLMA₅ (0.08 mg•kg^-1, D₁) on a Kunming S180 sarcoma mouse model made through subcutaneous injection. Methods D₁ was given to tumor-bearing mice before chemotherapy, the growth of tumor was observed, chromosomal samples of bone marrow cells of mice were prepared and the activities of free radicals of liver were measured. Results The grow velocity was significantly decreased (P<0.05~0.001), the chromosome aberrations of bone marrow cells were significantly reduced (P<0.01), SOD activity of liver was increased markedly (P<0.05), the activity of GSH -Px also had the trend of increasing and the content of MDA decreased significantly (P<0.01) when D₁ was given to the tumor-bearing mouse before larger dose BLMA₅(D₂) chemotherapy. Conclusion The chemotherapy effect enhanced with low dose BLMA₅ is associated with the increase of antioxidant capacity and the elimination capacity of free radicals products.

Key words: adaptive response, antineoplastic combined chemotherapy protocols, chromosome aberrations, free radicals

中图分类号:

R730.5

朴春姬，吕鹏，张海英，孙晓玲，王献理. 低剂量博来霉素A₅促进荷瘤小鼠化疗效果及其机制探讨[J]. J4, 2004, 30(3): 354-356.

PIAO Chun-ji, LU Peng, ZHANG Hai-ying, SUN Xiao-ling, WANG Xian-li. Antitumor effect of low dose BLMA₅ and its mechanisms[J]. J4, 2004, 30(3): 354-356.

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低剂量博来霉素A₅促进荷瘤小鼠化疗效果及其机制探讨

Antitumor effect of low dose BLMA₅ and its mechanisms

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