关键词: 结核, 胸膜, 免疫功能, 胸水

Abstract: Objective To study the effects of Utilin′s on the immune function and the pleural effusion absorption in patients with tuberculous pleurisy treated with antituberculotics. Methods The 43 tuberculous pleurisy patients were randomly divided into two groups, one group was treated with antituberculotics only (control group, n=23), the other group was treated with antituberculotics and Utilin′s (experimental group, n=20). The treatment duration was half year. The pleural effusion absorption was observed and the activities of IgG, IgA, IgM, CD3⁺, CD4⁺, CD8⁺ and NK of the 43 patients were measured before and after treament. Results ①In three months, the numbers in experimental group whose pleural effusion were absorped wholely were more than that in control group, and the difference was significant four months after treatment (P<0.05); ②Half year later, the levels of CD3⁺ and CD4⁺ in experimental group were significantly higher than those in control group (P<0.01), and NK cell activity in experimental group was significantly higher than that in control group (P<0.05), and the IgG level was increased (P<0.05). Conclusion Utilin′s can stimulate the immune system of tuberculous pleurisy patients and accelerate the pleural effusion absorption.

Key words: tuberculosis, pleural, immune function, hydrothorax