关键词: 婴儿, 新生, 白细胞介素4, 干扰素Ⅱ型, 肿瘤坏死因子

Abstract: Objective To observe the TOROH(including CMV,RV,TOX,and HSV) infections of newborns in hospital and study the changes of the levels of IL-4, IFN-γ, and TNF-α, respectively,in serum. Methods The neonates were given serum TORCH-IgM tests by ELISA.The levels of IL-4, IFN-γ, and TNF-α were all detected by double antibody with filling ELISA. Results There were altogether 18 patients with positive TORCH-IgM of 65 neonates in hospital. Among them there were 14 patients with positive CMV-IgM, 8 with TOX-IgM, 5 with positive HSV₂-IgM, and 3 with positive RV-IgM. The infect rates were 21.54%,12.31%,7.69%, and 4.62%, respectively,among neonates in hospital at the same time .The levels of IL-4, IFN-γ, and TNF-α in patients with positive TORCH-IgM were 20.47±2.55,292.6±73.9,and 219.11±22.27 ng•L^-1,respectively, while those in normal control group were 27.11±8.97,204.5±25.7, and 147.74±20.19　ng•L^-1,respectively. The level of IL-4 of patients with positive TORCH-IgM decreased (P<0.05),the levels of IFN-γ and TNF-α increased (P<0.05),compared with control group.　 Conclusion TORCH infection is very common in neonates in hospital. The detection rate of positive CMV-IgM is the highest, TOX-IgM comes next. After TORCH infection, the balance of immune is destroyed, and cytokines are secreted imbalanced. In the TORCH infection treatment, the immunity adjusting treatment should be emphasized besides anti-pathogen therapy.

Key words: infant, newborn, interleukin-4, interferon typeⅡ, tumor necrosis factor