关键词: 帕金森病, 病因学, 谷胱甘肽, 自由基

Abstract: Objective To explore the role of 6-hydroxydopamine in the pathogenesis of Parkinson′s disease(PD). Methods The 6-hydroxydopamine(6-OHDA) was stereotaxically injected into the right striatum of rat to build the PD model. After two months, the levels of glutathione (GSH) and reactive oxygen in the striatum were measured, and the pathological changes in the substantia nigra (SN) were observed. Results The level of GSH of right side of striatum in model groups （36.85±8.64 μg•mg^-1 prot） decreased significantly and the level of reactive oxygen （58.69±9.84 U•mg^-1 prot）increased markedly. There were significant differences between the right and left striatum in animal model groups (P<0.05). Compared with the sham group and control group, there were also significant differences (P<0.05). The dopaminergic neuron number in the right SN in model group decreased significantly compared with the left SN, sham group, and control group (P<0.05). Conclusion 6-OHDA can increase the level of free radicals and decrease the level of GSH, thus leading to the oxidative lesions in SN and striatum and neuronal death.

Key words: Parkinson disease, etiology, glutathione, free radicals