关键词: 基因, 肿瘤抑制, 基因, p16, p15, 免疫组织化学

Abstract: Objective To study the expressions of p16 and p15 in human endometrial carcinoma，atypical hyperplasia of endometrium, and normal endometrium and its significances. Methods The expressions of p16 and p15 was examined in 57 specimens of malignant, 8 specimens of borderline,7 specimens of benign uterine endometrial tissues and 7 specimens of normal endometrium by immunohistochemistry S-P methods. Results The positive rates of p16 expression in the malignant and non-malignant tissues were 40.4% and 77.3%, respectively, significant difference was observed (P<0.05). The expression of p16 was associated with pathological types, pathological grades and operation-pathology stages, but no association was found with muscle infiltrations. The positive rates of p15 expression in the malignant and non-malignant tissues were 47.4% and 86.3%, respectively, significant difference was observed (P<0.05). The expression of p15 was associated with pathological grades, but no association was found with pathological types, muscle infiltrations, and operation-pathology stages. There was positive correlation between p16 expression and p15 expression in uterine endometrial carcinoma（r=0.91，P<0.05）. Conclusion Low expressions of p16 and p15 may contribute to the development of uterine endometrial carcinoma.

Key words: genes, tumor suppressor, genes, p16, p15, immunohistochemistry