关键词:  , 原发性高血压, 血管紧张素Ⅱ1型受体, 基因多态性, 维吾尔族

Abstract:

Objective To investigate the association between angiotensin Ⅱ type 1 receptor (AT1R) gene A1166C polymorphism and essential hypertension (
EH) in Uygur nationality and to clarify the action mechanism of AT1R gene A1166C in the occ
urrence of EH.Methods 636 cases of Uyghur population blood samples including 167 cases of EH group and 469 cases of control group were collected.
Then polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP )method was adopted to examine the AT1R gene A1166C polymorphism.The distribution of AA,AC and CC genotypes and the different frequencies of the points A,C in EH and  control groups were analyzed.
Results The AC+CC genotype and C allele frequency in EH group were significantly higher than those in control group,the difference was statistically significant（χ2=10.179 ，P=0.001）;the  risk of EH of the people with AC+CC genotypes was 1.6（OR=1.612，95%CL:1.191-2.183）times than that of the people with AA genotype.Conclusion There might be some relationship between AT1R gene A1166C polymorphism and the EH in Uighur population.

Key words: essential hypertension, gene polymorphism, angiotensionⅡtype 1 receptor, Uygur nationality